http://purl.org/np/RA1wdolSsDlDIIS_SDqYQY3iGePHKVjDsXx_MOPFW3XOs#Head
http://purl.org/np/RA1wdolSsDlDIIS_SDqYQY3iGePHKVjDsXx_MOPFW3XOs
http://www.nanopub.org/nschema#hasAssertion
http://purl.org/np/RA1wdolSsDlDIIS_SDqYQY3iGePHKVjDsXx_MOPFW3XOs#assertion
http://purl.org/np/RA1wdolSsDlDIIS_SDqYQY3iGePHKVjDsXx_MOPFW3XOs
http://www.nanopub.org/nschema#hasProvenance
http://purl.org/np/RA1wdolSsDlDIIS_SDqYQY3iGePHKVjDsXx_MOPFW3XOs#provenance
http://purl.org/np/RA1wdolSsDlDIIS_SDqYQY3iGePHKVjDsXx_MOPFW3XOs
http://www.nanopub.org/nschema#hasPublicationInfo
http://purl.org/np/RA1wdolSsDlDIIS_SDqYQY3iGePHKVjDsXx_MOPFW3XOs#pubInfo
http://purl.org/np/RA1wdolSsDlDIIS_SDqYQY3iGePHKVjDsXx_MOPFW3XOs
http://www.w3.org/1999/02/22-rdf-syntax-ns#type
http://www.nanopub.org/nschema#Nanopublication
http://purl.org/np/RA1wdolSsDlDIIS_SDqYQY3iGePHKVjDsXx_MOPFW3XOs#assertion
http://identifiers.org/drugbank/DB00289
http://www.w3.org/1999/02/22-rdf-syntax-ns#type
https://w3id.org/biolink/vocab/Drug
http://identifiers.org/drugbank/DB00289
http://www.w3.org/2000/01/rdf-schema#label
Atomoxetine
http://identifiers.org/drugbank/DB00289
https://w3id.org/biolink/vocab/category
https://w3id.org/biolink/vocab/Drug
http://purl.obolibrary.org/obo/MONDO_0005689
http://www.w3.org/1999/02/22-rdf-syntax-ns#type
https://w3id.org/biolink/vocab/Disease
http://purl.obolibrary.org/obo/MONDO_0005689
http://www.w3.org/2000/01/rdf-schema#label
Cannabis dependence
http://purl.obolibrary.org/obo/MONDO_0005689
https://w3id.org/biolink/vocab/category
https://w3id.org/biolink/vocab/Disease
http://purl.org/np/RA1wdolSsDlDIIS_SDqYQY3iGePHKVjDsXx_MOPFW3XOs#association
http://www.w3.org/1999/02/22-rdf-syntax-ns#object
http://purl.obolibrary.org/obo/MONDO_0005689
http://purl.org/np/RA1wdolSsDlDIIS_SDqYQY3iGePHKVjDsXx_MOPFW3XOs#association
http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate
https://w3id.org/biolink/vocab/treats
http://purl.org/np/RA1wdolSsDlDIIS_SDqYQY3iGePHKVjDsXx_MOPFW3XOs#association
http://www.w3.org/1999/02/22-rdf-syntax-ns#subject
http://identifiers.org/drugbank/DB00289
http://purl.org/np/RA1wdolSsDlDIIS_SDqYQY3iGePHKVjDsXx_MOPFW3XOs#association
http://www.w3.org/1999/02/22-rdf-syntax-ns#type
https://w3id.org/biolink/vocab/ChemicalToDiseaseOrPhenotypicFeatureAssociation
http://purl.org/np/RA1wdolSsDlDIIS_SDqYQY3iGePHKVjDsXx_MOPFW3XOs#association
http://www.w3.org/2000/01/rdf-schema#label
Currently, there are no FDA-approved pharmacotherapies available for CUD, though a number (eg, cannabinoids, antidepressants, anxiolytics, and glutamatergic modulators) have been proposed for off-label use. We identified 12 trials examining psychopharmacological interventions for the treatment of cannabis use disorder. Trials examined antidepressants (ie, escitalopram, fluoxetine, bupropion, nefazodone, venlafaxine, vilazodone), antipsychotics (ie, clozapine, ziprasidone), buspirone, mood stabilizers (ie, divalproex, lithium), and atomoxetine. Overall, studies found that antidepressants as a class were less effective than placebo for the achievement of abstinence (moderate SOE). There was no difference between antidepressants (moderate SOE) or buspirone (low SOE) and placebo in reducing overall cannabis use or retention in treatment. We found low strength evidence of no difference from placebo for antidepressants or buspirone on harms. Antidepressant medications did not impact secondary outcomes (low SOE). Findings for all other psychopharmacotherapies and drug/outcome combinations were either insufficient or were not identified in the current literature.
http://purl.org/np/RA1wdolSsDlDIIS_SDqYQY3iGePHKVjDsXx_MOPFW3XOs#association
https://w3id.org/biolink/vocab/aggregator_knowledge_source
https://w3id.org/biolink/infores/knowledge-collaboratory
http://purl.org/np/RA1wdolSsDlDIIS_SDqYQY3iGePHKVjDsXx_MOPFW3XOs#association
https://w3id.org/biolink/vocab/category
https://w3id.org/biolink/vocab/ChemicalToDiseaseOrPhenotypicFeatureAssociation
http://purl.org/np/RA1wdolSsDlDIIS_SDqYQY3iGePHKVjDsXx_MOPFW3XOs#association
https://w3id.org/biolink/vocab/has_population_context
http://purl.org/np/RA1wdolSsDlDIIS_SDqYQY3iGePHKVjDsXx_MOPFW3XOs#context
http://purl.org/np/RA1wdolSsDlDIIS_SDqYQY3iGePHKVjDsXx_MOPFW3XOs#association
https://w3id.org/biolink/vocab/publications
http://www.ncbi.nlm.nih.gov/pubmed/32227801
http://purl.org/np/RA1wdolSsDlDIIS_SDqYQY3iGePHKVjDsXx_MOPFW3XOs#association
https://w3id.org/biolink/vocab/relation
http://purl.obolibrary.org/obo/NCIT_C94303
http://purl.org/np/RA1wdolSsDlDIIS_SDqYQY3iGePHKVjDsXx_MOPFW3XOs#context
http://www.w3.org/1999/02/22-rdf-syntax-ns#type
https://w3id.org/biolink/vocab/Cohort
http://purl.org/np/RA1wdolSsDlDIIS_SDqYQY3iGePHKVjDsXx_MOPFW3XOs#context
http://www.w3.org/2000/01/rdf-schema#label
Adults
http://purl.org/np/RA1wdolSsDlDIIS_SDqYQY3iGePHKVjDsXx_MOPFW3XOs#context
https://w3id.org/biolink/vocab/category
https://w3id.org/biolink/vocab/Cohort
http://purl.org/np/RA1wdolSsDlDIIS_SDqYQY3iGePHKVjDsXx_MOPFW3XOs#provenance
http://purl.org/np/RA1wdolSsDlDIIS_SDqYQY3iGePHKVjDsXx_MOPFW3XOs#assertion
http://www.w3.org/ns/prov#wasAttributedTo
https://orcid.org/0000-0002-7641-6446
http://purl.org/np/RA1wdolSsDlDIIS_SDqYQY3iGePHKVjDsXx_MOPFW3XOs#pubInfo
http://purl.org/np/RA1wdolSsDlDIIS_SDqYQY3iGePHKVjDsXx_MOPFW3XOs#sig
http://purl.org/nanopub/x/hasAlgorithm
RSA
http://purl.org/np/RA1wdolSsDlDIIS_SDqYQY3iGePHKVjDsXx_MOPFW3XOs#sig
http://purl.org/nanopub/x/hasPublicKey
MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCR9fz0fKCdWOWC+pxhkQhEM/ppbdIYe5TLSdj+lJzSlv9mYBaPgrzVezSwwbmhlHBPDZa4/vHycU315BdmUGq+pXllp9+rWFfrb+kBJwhZjpG6BeyyXBsRFz4jmQVxl/ZYHilQTh/XalYzKkEAyTiEMPee4Kz61PaWOKH24CsnOQIDAQAB
http://purl.org/np/RA1wdolSsDlDIIS_SDqYQY3iGePHKVjDsXx_MOPFW3XOs#sig
http://purl.org/nanopub/x/hasSignature
D8GsasOjHvLYmnRmAceK95Jmdtplh7F3BH2xwHnRk7C+BacNwaLzEOT/yIBL+K0hWVSu17yIGcICLAKqsdhcua9tAcDaaoZMZlCtEZhpXf6zKRmpImBNj6FLWLS5bPoQBKxe0svoCnqZQx0YgoGwQDgIgBEcbdWNYxIdCLlQEMc=
http://purl.org/np/RA1wdolSsDlDIIS_SDqYQY3iGePHKVjDsXx_MOPFW3XOs#sig
http://purl.org/nanopub/x/hasSignatureTarget
http://purl.org/np/RA1wdolSsDlDIIS_SDqYQY3iGePHKVjDsXx_MOPFW3XOs
http://purl.org/np/RA1wdolSsDlDIIS_SDqYQY3iGePHKVjDsXx_MOPFW3XOs
http://www.w3.org/ns/prov#generatedAtTime
2022-09-16T11:52:04.441645
http://purl.org/np/RA1wdolSsDlDIIS_SDqYQY3iGePHKVjDsXx_MOPFW3XOs
http://www.w3.org/ns/prov#wasAttributedTo
https://orcid.org/0000-0002-1501-1082
http://purl.org/np/RA1wdolSsDlDIIS_SDqYQY3iGePHKVjDsXx_MOPFW3XOs
https://w3id.org/np/o/ntemplate/wasCreatedFromTemplate
http://purl.org/np/RAhNHZw6Urw_Mccs4qy6Ws3C9CRuaHpQx8AwuApbWkqnY
https://w3id.org/biolink/vocab/
http://purl.org/pav/version
2.3.0