@prefix this: <https://w3id.org/np/RA6TVqiMTttbHd7HqvqQ9yABhCrfAenX7M5EfO9TAA4yo> .
@prefix sub: <https://w3id.org/np/RA6TVqiMTttbHd7HqvqQ9yABhCrfAenX7M5EfO9TAA4yo/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix npx: <http://purl.org/nanopub/x/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  <arcp://name,uts_public_data_repo/29ff7e9014ff11eeacf4b15b8fae1d4e> dct:conformsTo
      <https://w3id.org/ldac/profile#Object>;
    <http://schema.org/citation> <https://doi.org/10.26195/yy89-dk26>, <https://link.springer.com/article/10.1007/s00109-021-02122-x>,
      <https://onlinelibrary.wiley.com/doi/10.1111/1753-0407.13252>;
    <http://schema.org/conditionsOfAccess> "Please contact the data manager for this publication for access";
    <http://schema.org/contactPoint> sub:_1;
    <http://schema.org/contentUrl> "./";
    <http://schema.org/creator> <https://data.research.uts.edu.au/api/object/Bronwyn.Obrien@uts.edu.au>,
      <https://data.research.uts.edu.au/api/object/Inah.Camaya@uts.edu.au>, <https://data.research.uts.edu.au/api/object/Sheila.Donnelly@uts.edu.au>;
    <http://schema.org/dateCreated> "2023-07-05T23:56:09.003Z";
    <http://schema.org/datePublished> "2023-07-05T23:56:09.003Z";
    <http://schema.org/description> """Supplementary files relating the the analysis of the differential abundance of proteins and the differential expression of miRNA:mRNA in beta cells treated with FhHDM-1 under basal and apoptotic conditions.

Supplementary Table 3.1. Proteins with significantly different abundance in FhHDM-1 treated β-cells compared to untreated controls

Supplementary Table 4.1. Predicted gene targets for differentially expressed miRNAs in FhHDM-1 treated β-cells compared to untreated (Un) controls

Supplementary Table 4.2. Predicted gene targets of differentially expressed miRNAs in FhHDM-1 treated β-cells compared to untreated (Un) controls, common across all online miRNA gene target prediction tools mIRDB, DIANA and Target Scan

Supplementary Table 4.3A. List of predicted gene targets from miRNA upregulated in FhHDM-1 treated β-cells within each PANTHER DB category of molecular function and biological process (from Figure 2).

Supplementary Table 4.3B. KEGG pathway analysis of predicted gene targets from miRNA downregulated in FhHDM-1 treated β-cells compared to untreated controls

Supplementary Table 4.4. List of matched gene targets from miRNA downregulated in FhHDM-1 treated β-cells within each PANTHER DB category of molecular function and biological process (from Figure 4.5).

Supplementary Table 4.5. Differentially expressed miRNAs in FhHDM-1 treated β-cells exposed to pro-inflammatory cytokines, compared to cytokines alone

Supplementary Table 4.6. Predicted gene targets for differentially expressed miRNAs in FhHDM-1 treated β-cells exposed to pro-inflammatory cytokines compared to cytokines (CM) alone

Supplementary Table 4.7. Predicted gene targets of differentially expressed miRNAs in FhHDM-1 treated β-cells exposed to pro-inflammatory cytokines compared to cytokines (CM) alone, common across all online miRNA gene target prediction tools mIRDB, DIANA and Target Scan

Supplementary Table 4.8. KEGG pathway analysis of predicted gene targets from miRNA upregulated in FhHDM-1 treated β-cells exposed to pro-inflammatory cytokines compared to cytokines alone

Supplementary Table 4.9. KEGG pathway analysis of predicted gene targets from miRNA downregulated in FhHDM-1 treated β-cells exposed to pro-inflammatory cytokines compared to cyokines alone

Supplementary Table 4.10. Differentially expressed genes in the transcriptome of FhHDM-1 treated β-cells exposed to pro-inflammatory cytokines, compared to cytokines alone

Supplementary Table 4.11. Matched gene targets common between transcriptome and predicted gene targets of differentially expressed miRNA in FhHDM-1 treated β-cells under inflammatory conditions compared to pro-inflammatory cytokine only (CM) controls.

Supplementary Table 4.12. KEGG pathway analysis of matched genes downregulated in the transcriptome with their corresponding regulatory miRNA upregulated in FhHDM-1 β-cells exposed to pro-inflammatory cytokines compared to cytokines alone

Supplementary Table 4.13. KEGG pathway analysis of matched genes upregulated in the transcriptome with their corresponding regulatory miRNA downregulated in FhHDM-1 β-cells exposed to pro-inflammatory cytokines compared to cytokines alone
""";
    <http://schema.org/identifier> "29ff7e9014ff11eeacf4b15b8fae1d4e", sub:_2, sub:_3;
    <http://schema.org/keywords> "Fasciola", "FhHDM", "IGF", "PI3K", "apoptosis", "beta cell",
      "helminth", "miRNA", "type 1 diabetes";
    <http://schema.org/license> sub:_4;
    <http://schema.org/memberOf> <arcp://name,uts_public_data_repo/uts_root_collection>;
    <http://schema.org/name> "Inah Camaya PhD - Supplementary Data";
    <http://schema.org/publisher> <https://www.uts.edu.au/>;
    <http://schema.org/spatialCoverage> sub:_5;
    <http://schema.org/temporalCoverage> "2023-06-30/2029-12-31; N/A";
    <http://schema.org/yearCreated> "2023";
    <http://schema.org/yearPublished> "2023";
    a <http://pcdm.org/models#Object>, <http://schema.org/Dataset> .
  
  <arcp://name,uts_public_data_repo/uts_root_collection> dct:conformsTo <https://w3id.org/ldac/profile#Collection>;
    <http://schema.org/description> "This is the UTS Research Data Portal. For any questions, please get in touch with us at eResearch-it@uts.edu.au";
    <http://schema.org/license> sub:_6;
    <http://schema.org/name> "UTS Research Data Portal";
    a <http://pcdm.org/models#Collection>, <http://schema.org/Dataset> .
  
  <git+https://github.com/Arkisto-Platform/oni-ocfl.git> <http://schema.org/description>
      "Oni ocfl tools";
    <http://schema.org/name> "git+https://github.com/Arkisto-Platform/oni-ocfl.git";
    <http://schema.org/programmingLanguage> <https://en.wikipedia.org/wiki/Node.js>;
    a <http://schema.org/SoftwareSourceCode> .
  
  <https://data.research.uts.edu.au/api/object/Bronwyn.Obrien@uts.edu.au> <http://schema.org/affiliation>
      <https://www.uts.edu.au/>;
    <http://schema.org/email> "Bronwyn.Obrien@uts.edu.au";
    <http://schema.org/familyName> "O'Brien";
    <http://schema.org/givenName> "Bronwyn";
    <http://schema.org/identifier> "Bronwyn.Obrien@uts.edu.au";
    <http://schema.org/name> "Bronwyn O'Brien";
    a <http://schema.org/Person> .
  
  <https://data.research.uts.edu.au/api/object/Inah.Camaya@uts.edu.au> <http://schema.org/affiliation>
      <https://www.uts.edu.au/>;
    <http://schema.org/email> "Inah.Camaya@uts.edu.au";
    <http://schema.org/familyName> "Camaya";
    <http://schema.org/givenName> "Inah";
    <http://schema.org/identifier> "Inah.Camaya@uts.edu.au";
    <http://schema.org/name> "Inah Camaya";
    a <http://schema.org/Person> .
  
  <https://data.research.uts.edu.au/api/object/Sheila.Donnelly@uts.edu.au> <http://schema.org/affiliation>
      <https://www.uts.edu.au/>;
    <http://schema.org/contactPoint> "_:contact/Sheila.Donnelly@uts.edu.au";
    <http://schema.org/email> "Sheila.Donnelly@uts.edu.au";
    <http://schema.org/familyName> "Donnelly";
    <http://schema.org/givenName> "Sheila";
    <http://schema.org/identifier> "Sheila.Donnelly@uts.edu.au";
    <http://schema.org/name> "Sheila Donnelly";
    a <http://schema.org/Person> .
  
  <https://data.research.uts.edu.au/api/object/crystal.yip@uts.edu.au> <http://schema.org/email>
      "crystal.yip@uts.edu.au";
    a <http://schema.org/Person> .
  
  <https://data.research.uts.edu.au/api/object/entity-1> a <http://schema.org/GeoCoordinates> .
  
  <https://data.research.uts.edu.au/api/object/history1> <http://schema.org/agent> <https://data.research.uts.edu.au/api/object/sheila.donnelly@uts.edu.au>;
    <http://schema.org/description> "Data record created";
    <http://schema.org/endTime> "2023-07-05T23:56:09.003Z";
    <http://schema.org/name> "Create";
    <http://schema.org/object> <https://data.research.uts.edu.au/api/object/>;
    a <http://schema.org/CreateAction> .
  
  <https://data.research.uts.edu.au/api/object/history2> <http://schema.org/agent> <https://data.research.uts.edu.au/api/object/crystal.yip@uts.edu.au>;
    <http://schema.org/endTime> "2023-07-05T23:56:09.003Z";
    <http://schema.org/name> "Publish";
    <http://schema.org/object> <https://data.research.uts.edu.au/api/object/>;
    a <http://schema.org/UpdateAction> .
  
  <https://data.research.uts.edu.au/api/object/meta?resolve-parts&noUrid&id=arcp://name,uts_public_data_repo/29ff7e9014ff11eeacf4b15b8fae1d4e#provenance>
    <http://schema.org/instrument> <git+https://github.com/Arkisto-Platform/oni-ocfl.git>;
    <http://schema.org/name> "Created RO-Crate using oni-ocfl";
    <http://schema.org/result> <https://data.research.uts.edu.au/api/object/ro-crate-metadata.json>;
    a <http://schema.org/CreateAction> .
  
  <https://data.research.uts.edu.au/api/object/ro-crate-metadata.json> dct:conformsTo
      <https://w3id.org/ldac/profile#Object>;
    <http://schema.org/about> <arcp://name,uts_public_data_repo/29ff7e9014ff11eeacf4b15b8fae1d4e>;
    <http://schema.org/identifier> "ro-crate-metadata.json";
    a <http://schema.org/CreativeWork> .
  
  <https://data.research.uts.edu.au/api/object/ro-crate-metadata.jsonld> <http://schema.org/about>
      <https://data.research.uts.edu.au/api/object/>;
    <http://schema.org/identifier> "ro-crate-metadata.jsonld";
    a <http://schema.org/CreativeWork> .
  
  <https://data.research.uts.edu.au/api/object/sheila.donnelly@uts.edu.au> <http://schema.org/email>
      "sheila.donnelly@uts.edu.au";
    a <http://schema.org/Person> .
  
  <https://doi.org/10.26195/yy89-dk26> <http://schema.org/identifier> "https://doi.org/10.26195/yy89-dk26";
    <http://schema.org/name> "DOI";
    a <http://schema.org/CreativeWork> .
  
  <https://link.springer.com/article/10.1007/s00109-021-02122-x> <http://schema.org/description>
      "Camaya I, Mok TY, Lund M, To J, Braidy N, Robinson MW, Santos J, O'Brien B, Donnelly S. The parasite-derived peptide FhHDM-1 activates the PI3K/Akt pathway to prevent cytokine-induced apoptosis of β-cells. J Mol Med (Berl). 2021 Nov;99(11):1605-1621. doi: 10.1007/s00109-021-02122-x.";
    <http://schema.org/identifier> "https://link.springer.com/article/10.1007/s00109-021-02122-x";
    <http://schema.org/name> "The parasite-derived peptide FhHDM-1 activates the PI3K/Akt pathway to prevent cytokine-induced apoptosis of β-cells";
    a <http://schema.org/ScholarlyArticle> .
  
  <https://onlinelibrary.wiley.com/doi/10.1111/1753-0407.13252> <http://schema.org/description>
      "Camaya I, Donnelly S, O'Brien B. Targeting the PI3K/Akt signaling pathway in pancreatic β-cells to enhance their survival and function: An emerging therapeutic strategy for type 1 diabetes. J Diabetes. 2022 Apr;14(4):247-260. doi: 10.1111/1753-0407.13252. ";
    <http://schema.org/identifier> "https://onlinelibrary.wiley.com/doi/10.1111/1753-0407.13252";
    <http://schema.org/name> "Targeting the PI3K/Akt signaling pathway in pancreatic β-cells to enhance their survival and function: An emerging therapeutic strategy for type 1 diabetes";
    a <http://schema.org/ScholarlyArticle> .
  
  sub:_1 <http://schema.org/contactType> "Data Manager";
    <http://schema.org/email> "Sheila.Donnelly@uts.edu.au";
    <http://schema.org/identifier> "_:contact/Sheila.Donnelly@uts.edu.au";
    a <http://schema.org/ContactPoint> .
  
  sub:_2 <http://schema.org/name> "public_ocfl";
    <http://schema.org/value> "29ff7e9014ff11eeacf4b15b8fae1d4e";
    a <http://schema.org/PropertyValue> .
  
  sub:_3 <http://schema.org/name> "repository";
    <http://schema.org/value> "arcp://name,uts_public_data_repo/29ff7e9014ff11eeacf4b15b8fae1d4e";
    a <http://schema.org/PropertyValue> .
  
  sub:_4 <http://schema.org/name> "http://creativecommons.org/licenses/by/3.0/au";
    <http://schema.org/url> "http://creativecommons.org/licenses/by/3.0/au";
    a <http://schema.org/CreativeWork> .
  
  sub:_5 <http://schema.org/geo> <https://data.research.uts.edu.au/api/object/entity-1>;
    <http://schema.org/identifier> "_:spatial/1";
    <http://schema.org/name> "N/A";
    a <http://schema.org/Place> .
  
  sub:_6 <http://schema.org/description> "You are free to share (copy and redistribute the material in any medium or format) and adapt (remix, transform and build upon the material for any purpose, even commercially).";
    <http://schema.org/name> "Attribution 4.0 International (CC BY 4.0)";
    a <http://schema.org/OrganizationReuseLicense> .
  
  <https://www.uts.edu.au/> <http://schema.org/identifier> "https://www.uts.edu.au/";
    <http://schema.org/name> "University of Technology Sydney";
    a <http://schema.org/Organization> .
}

sub:provenance {
  sub:assertion prov:wasDerivedFrom <https://data.research.uts.edu.au/api/object/meta?resolve-parts&noUrid&id=arcp%3A%2F%2Fname%2Cuts_public_data_repo%2F29ff7e9014ff11eeacf4b15b8fae1d4e> .
}

sub:pubinfo {
  this: dct:created "2025-07-18T14:08:56.193+02:00"^^xsd:dateTime;
    a npx:RoCrateNanopub .
  
  sub:sig npx:hasAlgorithm "RSA";
    npx:hasPublicKey "MIIBIjANBgkqhkiG9w0BAQEFAAOCAQ8AMIIBCgKCAQEApbztY8l4lWqVF8L/djJ1knoc7Nm5kVHT9NqSe0fXO9Hel3DRO2IyxJYVEvThhllBuHNtZK32ww23AlglArokhxPCSBPKvVgQS6r46khF2D85tnd5htaBq+bfjMqL+LDlQh3LdBpAqrLmsmfsPkU65CCxSGufBs2v39p41z5FkRXE1JKJ/UZe+1OUq+CibjOfo1g1Nz6HO0fZML7GnQBj5X9lvU0llmDk/sqdNMxAJDSQh2/Zh0kz7+Dm7vJOx3mNEXU4FuzVzKBYwTotvEcJod7Vot1fPOJXPGoNDVNKMQffCala9o4pqT739LS7R7ZFVMjzPkLUxYCjnEgOZI5t6wIDAQAB";
    npx:hasSignature "M8IMyo1gE8ODqgJI+GMSvTNLO+/guhCOWCPtZpQIbTVXaWMhHzy9lcg9as20m1pLN5mHaDeVxS0JJFL91KVZklD5K1oD7sE7ZKOguBUR79Urs6dQgOLn5hWzaPCahfu1vd99jFvxVZNOovxPsO71adll9W6mf78SjMp8gb6kwkgY44bcfzW9Dsd05HFun/w3ASqTdhphOni7sTvQ3vFl5xXyDUWYJXbkOYQmuFe5n1oTTCXTVkfKJwOkZsYpDmYdXoQcw86Hj/vKUlvkUsMAkrGA9mGMr9C+PHYGjLtPDmzpOgBRehXH8AWCBSMDGviZKR4+6oj3CSzl/0G8/sapXA==";
    npx:hasSignatureTarget this:;
    npx:signedBy <https://orcid.org/0009-0008-3635-347X> .
}