@prefix biolink: <https://w3id.org/biolink/vocab/> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix this: <http://purl.org/np/RA7wRogkbsj2tbG4zG0Mb1DiD0xuzAo0MWsw8wFwkQ45Q> .
@prefix sub: <http://purl.org/np/RA7wRogkbsj2tbG4zG0Mb1DiD0xuzAo0MWsw8wFwkQ45Q#> .
@prefix schema: <https://schema.org/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix nt: <https://w3id.org/np/o/ntemplate/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix orcid: <https://orcid.org/> .
@prefix nkg: <https://w3id.org/um/neurodkg/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix npx: <http://purl.org/nanopub/x/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:association rdf:object <https://identifiers.org/MONDO:0021668>;
    rdf:predicate biolink:treats;
    rdf:subject <https://identifiers.org/CHEBI:142406>;
    a rdf:Statement;
    rdfs:label "PRIALT (ziconotide) solution, intrathecal infusion is indicated for the management of severe chronic pain in adult patients for whom intrathecal therapy is warranted, and who are intolerant of or refractory to other treatment, such as systemic analgesics, adjunctive therapies, or intrathecal morphine";
    biolink:association_type biolink:ChemicalToDiseaseOrPhenotypicFeatureAssociation;
    biolink:has_population_context sub:cohort;
    biolink:provided_by "NeuroDKG";
    biolink:publications <https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b025d8ed-937d-4597-9ad1-0b2f6e0ee5b1>;
    biolink:relation nkg:SymptomaticReliefIndication .
  
  sub:cohort rdfs:label "adult patients for whom intrathecal therapy is warranted, and who are intolerant of or refractory to other treatment, such as systemic analgesics, adjunctive therapies, or intrathecal morphine";
    schema:requiredMinAge "18";
    biolink:category biolink:Cohort .
  
  <https://identifiers.org/CHEBI:142406> biolink:category biolink:Drug .
  
  <https://identifiers.org/MONDO:0021668> biolink:category biolink:Disease .
}

sub:provenance {
  sub:assertion prov:wasAttributedTo orcid:0000-0002-1468-3557 .
}

sub:pubinfo {
  sub:sig npx:hasAlgorithm "RSA";
    npx:hasPublicKey "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCODwZkXojpEKwk7Ldj2oPPfCstvqrcpgCaTLo235K7ht9C7E1GCkLvUuL2b4VWXJTcZx/hxgDauR8hUeYq/lS6tfTL9yFZsnfl+PWYDyz7vv6N+wJVx2LL8bO6ntCjcOzvW2t2WUeF12Sb6b3I6uOYP0N8iQKts1WasY/yEYKAHQIDAQAB";
    npx:hasSignature "dNUDeag4QuIhj20K/O/qc/ZEfRtAIheMDcH3xAnCCkjEpvQMgZ47uoWN2xQjV6vylBDCzdMwo4bIiORrY2TIHzENNzkLFm/Kxe/hGap1+4c5pIN+AcH5W3YtJK3yYcbOaCCM3BTGnPwQfkgWAZV4K2oXaiEbZa9BuPNyP+WRQtQ=";
    npx:hasSignatureTarget this: .
  
  this: dcterms:created "2021-03-28T19:00:44.352+02:00"^^xsd:dateTime;
    dcterms:creator orcid:0000-0002-1468-3557;
    nt:wasCreatedFromProvenanceTemplate <http://purl.org/np/RANwQa4ICWS5SOjw7gp99nBpXBasapwtZF1fIM3H2gYTM>;
    nt:wasCreatedFromPubinfoTemplate <http://purl.org/np/RAA2MfqdBCzmz9yVWjKLXNbyfBNcwsMmOqcNUxkk1maIM>;
    nt:wasCreatedFromTemplate <http://purl.org/np/RA59AEpaWRaR9sjdA0-n4zaQWdiZ6--iGafMrjrDAOheI> .
}