@prefix nkg: <https://w3id.org/um/neurodkg/> .
@prefix nt: <https://w3id.org/np/o/ntemplate/> .
@prefix orcid: <https://orcid.org/> .
@prefix bl: <https://w3id.org/biolink/vocab/> .
@prefix this: <http://purl.org/np/RAHTMDPT6XyaNv0R67W6y6nJwpAEHJF9fWpEuYXfoUtgo> .
@prefix sub: <http://purl.org/np/RAHTMDPT6XyaNv0R67W6y6nJwpAEHJF9fWpEuYXfoUtgo#> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix npx: <http://purl.org/nanopub/x/> .
sub:Head {
   this: np:hasAssertion sub:assertion ;
    np:hasProvenance sub:provenance ;
    np:hasPublicationInfo sub:pubInfo ;
    a np:Nanopublication .
}
sub:assertion {
   <http://purl.obolibrary.org/obo/MONDO_0007079> a bl:Disease .
  sub:association rdf:object <http://purl.obolibrary.org/obo/MONDO_0007079> ;
    rdf:predicate bl:treats ;
    rdf:subject <https://identifiers.org/DRUGBANK:DB00657> ;
    a rdf:Statement ;
    rdfs:label "The nicotinic-acetylcholine receptor (nAchR)- antagonist mecamylanine has been found to reduce the stimulus produced by ethanol in human lab studies. The nAchR-antagonist varenicline has also displayed positive effect in reducing alcohol consumption in multiple clinical trials. In this 12- week double-blind trial, participants (n 1⁄4 126) were randomized to either mecamylamine (10 mg daily) or placebo. No medication effect was found for reducing heavy drinking days (HDD) or alcohol craving. Smoking status had no effect on the results. The authors suggest that broad-spectrum nAchR-antagonists may not be beneficial in treat- ing AUD" ;
    bl:has_population_context sub:context ;
    bl:provided_by <https://w3id.org/um/NeuroDKG> ;
    bl:publications <https://pubmed.ncbi.nlm.nih.gov/30973369> ;
    bl:relation nkg:OffLabelIndication .
  sub:context a bl:Cohort ;
    rdfs:label "Adults" .
  <https://identifiers.org/DRUGBANK:DB00657> a bl:Drug .
}
sub:provenance {
   sub:assertion prov:generatedAtTime "2021-08-24T17:09:05.806678"^^xsd:dateTime .
}
sub:pubInfo {
   sub:sig npx:hasAlgorithm "RSA" ;
    npx:hasPublicKey "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCamPJb4SzqpLXn//XJ5dlVfzz6QI+RPmiJTLXF/by2JR7sHMKRsCQDFsYMlq8zGHghOIkjRP9dpLZUtZzUcHt3MXiFKEPo8eGzUe9p+JXKFC8xxkJr94z2vq6IdMf71Iu1GH8SeDAKt/DgYO4zNaw8VuXvxnZRewKZSA+u8zWPVwIDAQAB" ;
    npx:hasSignature "PO5HBEoj7x+D/G0vO4/1JUbwcMW/hSz7lCyAXQkkDcaLd5K6ImX6hTC66Nhskuqc7JCniz4Vex+YM7aXXKJYA4w5A2JNUD/4dDc2g2CUul0MoKDDP3CYWcecfVke3BlK1FZa0uCHFnjIEmgo3wy5gdOjGpn7UgOzXzCm/vVJaqo=" ;
    npx:hasSignatureTarget this: .
  this: prov:generatedAtTime "2021-08-24T17:09:05.806678"^^xsd:dateTime ;
    prov:wasAttributedTo orcid:0000-0002-7641-6446 ;
    nt:wasCreatedFromTemplate <http://purl.org/np/RAhNHZw6Urw_Mccs4qy6Ws3C9CRuaHpQx8AwuApbWkqnY> .
}