@prefix bl: <https://w3id.org/biolink/vocab/> .
@prefix nkg: <https://w3id.org/um/neurodkg/> .
@prefix nt: <https://w3id.org/np/o/ntemplate/> .
@prefix orcid: <https://orcid.org/> .
@prefix this: <http://purl.org/np/RAMgA3pDhUWCduLgBk1ZqhDFXcNpxUcum_vmRW9vCdhe8> .
@prefix sub: <http://purl.org/np/RAMgA3pDhUWCduLgBk1ZqhDFXcNpxUcum_vmRW9vCdhe8#> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix npx: <http://purl.org/nanopub/x/> .
sub:Head {
   this: np:hasAssertion sub:assertion ;
    np:hasProvenance sub:provenance ;
    np:hasPublicationInfo sub:pubInfo ;
    a np:Nanopublication .
}
sub:assertion {
   <http://purl.obolibrary.org/obo/MONDO_0005277> a bl:Disease .
  sub:association rdf:object <http://purl.obolibrary.org/obo/MONDO_0005277> ;
    rdf:predicate bl:treats ;
    rdf:subject <https://identifiers.org/DRUGBANK:DB00321> ;
    a rdf:Statement ;
    rdfs:label "Although antidepressants are not the first-line prophylactic strategy for patients with migraine, several clinical trials have proven their effectiveness in the treatment of migraine and related headache disorders (Koch and Jurgens, 2009). Especially TCAs: amitriptyline (Couch and Hassanein, 1979; Jackson et al., 2010; Kalita et al., 2013) and nortriptyline (Holroyd et al., 2001; Jackson et al., 2010) have the best evidence for use in migraine prevention. When amitriptyline is not tolerated by patients, treatment is continued with nortriptyline (Burch, 2019)." ;
    bl:has_population_context sub:context ;
    bl:provided_by <https://w3id.org/um/NeuroDKG> ;
    bl:publications <https://pubmed.ncbi.nlm.nih.gov/31622593> ;
    bl:relation nkg:OffLabelIndication .
  sub:context a bl:Cohort ;
    rdfs:label "Adults" .
  <https://identifiers.org/DRUGBANK:DB00321> a bl:Drug .
}
sub:provenance {
   sub:assertion prov:generatedAtTime "2021-08-16T20:58:07.416019"^^xsd:dateTime .
}
sub:pubInfo {
   sub:sig npx:hasAlgorithm "RSA" ;
    npx:hasPublicKey "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCamPJb4SzqpLXn//XJ5dlVfzz6QI+RPmiJTLXF/by2JR7sHMKRsCQDFsYMlq8zGHghOIkjRP9dpLZUtZzUcHt3MXiFKEPo8eGzUe9p+JXKFC8xxkJr94z2vq6IdMf71Iu1GH8SeDAKt/DgYO4zNaw8VuXvxnZRewKZSA+u8zWPVwIDAQAB" ;
    npx:hasSignature "B7/KcuKQi6BEqCraWTskyVjmw0gI0NtvNM2px5+bjTLJMo/yPfB9MqN0kB4zsDflH+qsOZ2O5gID7R0//A4PjIuXVxWZt0wNAts1c9DhpuNzp92GJX6kJuCg0+3a4rjQhUUeYcaf9MQegnE7M1u5YuC/dZDPYgiymKf4ryDPYjw=" ;
    npx:hasSignatureTarget this: .
  this: prov:generatedAtTime "2021-08-16T20:58:07.416019"^^xsd:dateTime ;
    prov:wasAttributedTo orcid:0000-0002-7641-6446 ;
    nt:wasCreatedFromTemplate <http://purl.org/np/RAhNHZw6Urw_Mccs4qy6Ws3C9CRuaHpQx8AwuApbWkqnY> .
}