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All variants are annotated with structural descriptors derived from AlphaFold-2 predicted structures and augmented with sequence-based biophysical predictors such as disorder, flexibility, and amyloid aggregation propensity from the Bio2Byte suite. To complement structural predictions, empirical measurements of ACE2 binding affinity and surface expression levels were integrated for each 1-step variant, based on deep mutational scanning (DMS) data published by Starr et al. 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