sub:assertion {
  biolink:actively_involved_in rdfs:label "actively involved in - holds between a continuant and a process or function, where the continuant actively contributes to part or all of the process or function it realizes" .
  biolink:affected_by rdfs:label "affected by - describes an entity of which the state or quality is affected by another existing entity." .
  biolink:affects rdfs:label "affects - describes an entity that has a direct affect on the state or quality of another existing entity. Use of the 'affects' predicate implies that the affected entity already exists, unlike predicates such as 'affects risk for' and 'prevents, where the outcome is something that may or may not come to be." .
  biolink:affects_risk_for rdfs:label "affects risk for - holds between two entities where exposure to one entity alters the chance of developing the other" .
  biolink:ameliorates rdfs:label "ameliorates - A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure, clinical intervention) and a condition (a phenotype or disease), where the presence of the entity reduces or eliminates some or all aspects of the condition." .
  biolink:assesses rdfs:label "assesses - The effect of a thing on a target was interrogated in some assay. A relationship between some perturbing agent (usually a chemical compound) and some target entity, where the affect of the perturbing agent on the target entity was interrogated in a particular assay. The target might be a particular protein, tissue, phenotype, whole organism, cell line, or other type of biological entity." .
  biolink:associated_with rdfs:label "associated with - Expresses a relationship between two named things where the relationship is typically generated statistically (though not in all cases), and is weaker than its child, 'correlated with', but stronger than its parent, 'related to'. This relationship holds between two concepts represented by variables for which a statistical dependence is demonstrated. E.g. the statement “Atrial Fibrillation (Afib) is associated with Myocardial Infarction (MI)” asserts that having Afib is not statistically independent from whether a patient will also have MI. Note that in Translator associations, the subject and object concepts may map exactly to the statistical variables, or represent related entities for which the variables serve as proxies in an Association (e.g. diseases, chemical entities or processes)." .
  biolink:associated_with_decreased_likelihood_of rdfs:label "associated with decreased likelihood of - Expresses a relationship between two named things where the relationship is typically generated statistically and the state or fact of something is less probable." .
  biolink:associated_with_increased_likelihood_of rdfs:label "associated with increased likelihood of - Expresses a relationship between two named things where the relationship is typically generated statistically and the state or fact of something is more probable." .
  biolink:associated_with_likelihood_of rdfs:label "associated with likelihood of - A a relationship that holds between two concepts represented by variables for which a statistical dependence is demonstrated, wherein the state or value of one variable predicts the future state or value of the other. E.g. the statement “An Atrial Fibrillation (Afib) diagnosis is associated with likelihood of a Myocardial Infarction (MI) diagnosis” asserts that the state of having Afib is associated with an increased or decreased likelihood that a patient will later exhibit MI." .
  biolink:associated_with_resistance_to rdfs:label "associated with resistance to - A relation that holds between a named thing and a chemical that specifies that the change in the named thing is found to be associated with the degree of resistance to treatment by the chemical." .
  biolink:associated_with_sensitivity_to rdfs:label "associated with sensitivity to - A relation that holds between a named thing and a chemical that specifies that the change in the named thing is found to be associated with the degree of sensitivity to treatment by the chemical." .
  biolink:binds rdfs:label "binds - A causal mechanism mediated by the direct contact between effector and target chemical or biomolecular entity, which form a stable physical interaction." .
  biolink:biomarker_for rdfs:label "biomarker for - holds between a measurable chemical entity and a disease or phenotypic feature, where the entity is used as an indicator of the presence or state of the disease or feature." .
  biolink:capable_of rdfs:label "capable of - holds between a physical entity and process or function, where the continuant alone has the ability to carry out the process or function." .
  biolink:caused_by rdfs:label "caused by - holds between two entities where the occurrence, existence, or activity of one is caused by the occurrence or generation of the other" .
  biolink:causes rdfs:label "causes - holds between two entities where the occurrence, existence, or activity of one causes the occurrence or generation of the other" .
  biolink:chemically_similar_to rdfs:label "chemically similar to - holds between one small molecule entity and another that it approximates for purposes of scientific study, in virtue of its exhibiting similar features of the studied entity." .
  biolink:coexists_with rdfs:label "coexists with - holds between two entities that are co-located in the same aggregate object, process, or spatio-temporal region" .
  biolink:coexpressed_with rdfs:label "coexpressed with - holds between any two genes or gene products, in which both are generally expressed within a single defined experimental context." .
  biolink:colocalizes_with rdfs:label "colocalizes with - holds between two entities that are observed to be located in the same place." .
  biolink:composed_primarily_of rdfs:label "composed primarily of - x composed_primarily_of_y if:more than half of the mass of x is made from parts of y." .
  biolink:condition_associated_with_gene rdfs:label "condition associated with gene - holds between a gene and a disease or phenotypic feature that may be influenced, contribute to, or be correlated with the gene or its alleles/products" .
  biolink:contraindicated_for rdfs:label "contraindicated for - Holds between a drug and a disease or phenotype, such that a person with that disease should not be treated with the drug." .
  biolink:contributes_to rdfs:label "contributes to - holds between two entities where the occurrence, existence, or activity of one causes or contributes to the occurrence or generation of the other" .
  biolink:correlated_with rdfs:label "correlated with - A relationship that holds between two concepts represented by variables for which a statistical dependence is demonstrated using a correlation analysis method." .
  biolink:decreased_likelihood_associated_with rdfs:label "decreased likelihood associated with - " .
  biolink:decreases_amount_or_activity_of rdfs:label "decreases amount or activity of - A grouping mixin to help with searching for all the predicates that decrease the amount or activity of the object." .
  biolink:decreases_response_to rdfs:label "decreases response to - holds between two chemical entities where the action or effect of one decreases the susceptibility of a biological entity or system (e.g. an organism, cell, cellular component, macromolecular machine mixin, biological or pathological process) to the other" .
  biolink:derives_from rdfs:label "derives from - holds between two distinct material entities, the new entity and the old entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity" .
  biolink:derives_into rdfs:label "derives into - holds between two distinct material entities, the old entity and the new entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity" .
  biolink:diagnoses rdfs:label "diagnoses - a relationship that identifies the nature of (an illness or other problem) by examination of the symptoms." .
  biolink:directly_physically_interacts_with rdfs:label "directly physically interacts with - A causal mechanism mediated by a direct contact between the effector and target entities (this contact may be weak or strong, transient or stable)." .
  biolink:disease_has_basis_in rdfs:label "disease has basis in - A relation that holds between a disease and an entity where the state of the entity has contribution to the disease." .
  biolink:disease_has_location rdfs:label "disease has location - A relationship between a disease and an anatomical entity where the disease has one or more features that are located in that entity." .
  biolink:disrupted_by rdfs:label "disrupted by - describes a relationship where the structure, function, or occurrence of one entity is degraded or interfered with by another." .
  biolink:disrupts rdfs:label "disrupts - describes a relationship where one entity degrades or interferes with the structure, function, or occurrence of another." .
  biolink:enabled_by rdfs:label "enabled by - holds between a process and a physical entity, where the physical entity executes the process" .
  biolink:enables rdfs:label "enables - holds between a physical entity and a process, where the physical entity executes the process" .
  biolink:exacerbates rdfs:label "exacerbates - A relationship between an entity (e.g. a chemical, environmental exposure, or some form of genetic variation) and a condition (a phenotype or disease), where the presence of the entity worsens some or all aspects of the condition." .
  biolink:expressed_in rdfs:label "expressed in - holds between a gene or gene product and an anatomical entity in which it is expressed" .
  biolink:expresses rdfs:label "expresses - holds between an anatomical entity and gene or gene product that is expressed there" .
  biolink:food_component_of rdfs:label "food component of - holds between a one or more chemical entities present in food, irrespective of nutritional value (i.e. could also be a contaminant or additive)" .
  biolink:gene_associated_with_condition rdfs:label "gene associated with condition - holds between a gene and a disease or phenotypic feature that the gene or its alleles/products may influence, contribute to, or correlate with" .
  biolink:gene_fusion_with rdfs:label "gene fusion with - holds between two independent genes that have fused through translocation, interstitial deletion, or chromosomal inversion to form a new, hybrid gene. Fusion genes are often implicated in various neoplasms and cancers." .
  biolink:gene_product_of rdfs:label "gene product of - definition x has gene product of y if and only if y is a gene (SO:0000704) that participates in some gene expression process (GO:0010467) where the output of thatf process is either y or something that is ribosomally translated from x" .
  biolink:genetic_association rdfs:label "genetic association - Co-occurrence of a certain allele of a genetic marker and the phenotype of interest in the same individuals at above-chance level" .
  biolink:genetic_neighborhood_of rdfs:label "genetic neighborhood of - holds between two genes located nearby one another on a chromosome. " .
  biolink:genetically_interacts_with rdfs:label "genetically interacts with - holds between two genes whose phenotypic effects are dependent on each other in some way - such that their combined phenotypic effects are the result of some interaction between the activity of their gene products. Examples include epistasis and synthetic lethality." .
  biolink:has_active_ingredient rdfs:label "has active ingredient - holds between a drug and a molecular entity in which the latter is a part of the former, and is a biologically active component" .
  biolink:has_adverse_event rdfs:label "has adverse event - An untoward medical occurrence in a patient or clinical investigation subject that happens during treatment with a therapeutic agent. Adverse events may be caused by something other than the drug or therapy being given and may include abnormal laboratory finding, symptoms, or diseases temporally associated with the treatment, whether or not considered related to the treatment. Adverse events are unintended effects that occur when a medication is administered correctly." .
  biolink:has_biomarker rdfs:label "has biomarker - holds between a disease or phenotypic feature and a measurable chemical entity that is used as an indicator of the presence or state of the disease or feature. # metabolite" .
  biolink:has_chemical_role rdfs:label "has chemical role - A role is particular behaviour which a chemical entity may exhibit." .
  biolink:has_completed rdfs:label "has completed - holds between an entity and a process that the entity is capable of and has completed" .
  biolink:has_excipient rdfs:label "has excipient - holds between a drug and a molecular entities in which the latter is a part of the former, and is a biologically inactive component" .
  biolink:has_food_component rdfs:label "has food component - holds between food and one or more chemical entities composing it, irrespective of nutritional value (i.e. could also be a contaminant or additive)" .
  biolink:has_gene_product rdfs:label "has gene product - holds between a gene and a transcribed and/or translated product generated from it" .
  biolink:has_input rdfs:label "has input - holds between a process and a continuant, where the continuant is an input into the process" .
  biolink:has_member rdfs:label "has member - Defines a mereological relation between a collection and an item." .
  biolink:has_metabolite rdfs:label "has metabolite - holds between two molecular entities in which the second one is derived from the first one as a product of metabolism" .
  biolink:has_mode_of_inheritance rdfs:label "has mode of inheritance - Relates a disease or phenotypic feature to its observed genetic segregation and assumed associated underlying DNA manifestation (i.e. autosomal, sex or mitochondrial chromosome)." .
  biolink:has_molecular_consequence rdfs:label "has molecular consequence - connects a sequence variant to a class describing the molecular consequence. E.g. SO:0001583" .
  biolink:has_not_completed rdfs:label "has not completed - holds between an entity and a process that the entity is capable of, but has not completed" .
  biolink:has_nutrient rdfs:label "has nutrient - one or more nutrients which are growth factors for a living organism" .
  biolink:has_output rdfs:label "has output - holds between a process and a continuant, where the continuant is an output of the process" .
  biolink:has_part rdfs:label "has part - holds between wholes and their parts (material entities or processes)" .
  biolink:has_participant rdfs:label "has participant - holds between a process and a continuant, where the continuant is somehow involved in the process" .
  biolink:has_phenotype rdfs:label "has phenotype - holds between a biological entity and a phenotype, where a phenotype is construed broadly as any kind of quality of an organism part, a collection of these qualities, or a change in quality or qualities (e.g. abnormally increased temperature). In SNOMEDCT, disorders with keyword 'characterized by' should translate into this predicate." .
  biolink:has_plasma_membrane_part rdfs:label "has plasma membrane part - Holds between a cell c and a protein complex or protein p if and only if that cell has as part a plasma_membrane[GO:0005886], and that plasma membrane has p as part." .
  biolink:has_sequence_location rdfs:label "has sequence location - holds between two nucleic acid entities when the subject can be localized in sequence coordinates on the object. For example, between an exon and a chromosome/contig." .
  biolink:has_side_effect rdfs:label "has side effect - An unintended, but predictable, secondary effect shown to be correlated with a therapeutic agent, drug or treatment. Side effects happen at normal, recommended doses or treatments, and are unrelated to the intended purpose of the medication." .
  biolink:has_variant_part rdfs:label "has variant part - holds between a nucleic acid entity and a nucleic acid entity that is a sub-component of it" .
  biolink:homologous_to rdfs:label "homologous to - holds between two biological entities that have common evolutionary origin" .
  biolink:in_cell_population_with rdfs:label "in cell population with - holds between two genes or gene products that are expressed in the same cell type or population" .
  biolink:in_complex_with rdfs:label "in complex with - holds between two genes or gene products that are part of (or code for products that are part of) in the same macromolecular complex" .
  biolink:in_linkage_disequilibrium_with rdfs:label "in linkage disequilibrium with - holds between two sequence variants, the presence of which are correlated in a population" .
  biolink:in_pathway_with rdfs:label "in pathway with - holds between two genes or gene products that are part of in the same biological pathway" .
  biolink:in_taxon rdfs:label "in taxon - connects an entity to its taxonomic classification. Only certain kinds of entities can be taxonomically classified; see 'thing with taxon'" .
  biolink:increased_likelihood_associated_with rdfs:label "increased likelihood associated with - " .
  biolink:increases_amount_or_activity_of rdfs:label "increases amount or activity of - A grouping mixin to help with searching for all the predicates that increase the amount or activity of the object." .
  biolink:increases_response_to rdfs:label "increases response to - holds between two chemical entities where the action or effect of one increases the susceptibility of a biological entity or system (e.g. an organism, cell, cellular component, macromolecular machine mixin, biological or pathological process) to the other" .
  biolink:interacts_with rdfs:label "interacts with - holds between any two entities that directly or indirectly interact with each other" .
  biolink:is_active_ingredient_of rdfs:label "is active ingredient of - holds between a molecular entity and a drug, in which the former is a part of the latter, and is a biologically active component" .
  biolink:is_excipient_of rdfs:label "is excipient of - holds between a molecular entity and a drug in which the former is a part of the latter, and is a biologically inactive component" .
  biolink:is_frameshift_variant_of rdfs:label "is frameshift variant of - holds between a sequence variant and a gene, such the sequence variant causes a disruption of the translational reading frame, because the number of nucleotides inserted or deleted is not a multiple of three." .
  biolink:is_metabolite_of rdfs:label "is metabolite of - holds between two molecular entities in which the first one is derived from the second one as a product of metabolism" .
  biolink:is_missense_variant_of rdfs:label "is missense variant of - holds between a gene and a sequence variant, such the sequence variant results in a different amino acid sequence but where the length is preserved." .
  biolink:is_nearby_variant_of rdfs:label "is nearby variant of - holds between a sequence variant and a gene sequence that the variant is genomically close to." .
  biolink:is_non_coding_variant_of rdfs:label "is non coding variant of - holds between a sequence variant and a gene, where the variant does not affect the coding sequence" .
  biolink:is_nonsense_variant_of rdfs:label "is nonsense variant of - holds between a sequence variant and a gene, such the sequence variant results in a premature stop codon" .
  biolink:is_sequence_variant_of rdfs:label "is sequence variant of - holds between a sequence variant and a nucleic acid entity" .
  biolink:is_splice_site_variant_of rdfs:label "is splice site variant of - holds between a sequence variant and a gene, such the sequence variant is in the canonical splice site of one of the gene's exons." .
  biolink:is_synonymous_variant_of rdfs:label "is synonymous variant of - holds between a sequence variant and a gene, such the sequence variant is in the coding sequence of the gene, but results in the same amino acid sequence" .
  biolink:likelihood_associated_with rdfs:label "likelihood associated with - " .
  biolink:located_in rdfs:label "located in - holds between a material entity and a material entity or site within which it is located (but of which it is not considered a part)" .
  biolink:location_of rdfs:label "location of - holds between material entity or site and a material entity that is located within it (but not considered a part of it)" .
  biolink:manifestation_of rdfs:label "manifestation of - that part of a phenomenon which is directly observable or visibly expressed, or which gives evidence to the underlying process; used in SemMedDB for linking things like dysfunctions and processes to some disease or syndrome" .
  biolink:member_of rdfs:label "member of - Defines a mereological relation between a item and a collection." .
  biolink:mentioned_by rdfs:label "mentioned by - refers to is a relation between one named thing and the information content entity that it makes reference to." .
  biolink:mentions rdfs:label "mentions - refers to is a relation between one information content entity and the named thing that it makes reference to." .
  biolink:model_of rdfs:label "model of - holds between a thing and some other thing it approximates for purposes of scientific study, in virtue of its exhibiting similar features of the studied entity." .
  biolink:molecular_activity_enabled_by rdfs:label "molecular activity enabled by - The gene product, gene, or complex that catalyzes the reaction" .
  biolink:molecular_activity_has_input rdfs:label "molecular activity has input - A chemical entity that is the input for the reaction" .
  biolink:molecular_activity_has_output rdfs:label "molecular activity has output - A chemical entity that is the output for the reaction" .
  biolink:negatively_correlated_with rdfs:label "negatively correlated with - A relationship that holds between two concepts represented by variables for which a statistical correlation is demonstrated, wherein variable values move in opposite directions (i.e. increased in one or presence of one correlates with a decrease or absence of the other)." .
  biolink:nutrient_of rdfs:label "nutrient of - holds between a one or more chemical entities present in food, irrespective of nutritional value (i.e. could also be a contaminant or additive)" .
  biolink:occurs_in rdfs:label "occurs in - holds between a process and a material entity or site within which the process occurs" .
  biolink:occurs_together_in_literature_with rdfs:label "occurs together in literature with - holds between two entities where their co-occurrence is correlated by counts of publications in which both occur, using some threshold of occurrence as defined by the edge provider." .
  biolink:opposite_of rdfs:label "opposite of - x is the opposite of y if there exists some distance metric M, and there exists no z such as M(x,z) <= M(x,y) or M(y,z) <= M(y,x). (This description is from RO. Needs to be rephrased)." .
  biolink:orthologous_to rdfs:label "orthologous to - a homology relationship between entities (typically genes) that diverged after a speciation event." .
  biolink:overlaps rdfs:label "overlaps - holds between entities that overlap in their extents (materials or processes)" .
  biolink:paralogous_to rdfs:label "paralogous to - a homology relationship that holds between entities (typically genes) that diverged after a duplication event." .
  biolink:part_of rdfs:label "part of - holds between parts and wholes (material entities or processes)" .
  biolink:participates_in rdfs:label "participates in - holds between a continuant and a process, where the continuant is somehow involved in the process" .
  biolink:physically_interacts_with rdfs:label "physically interacts with - holds between two entities that make physical contact as part of some interaction. does not imply a causal relationship." .
  biolink:positively_correlated_with rdfs:label "positively correlated with - A relationship that holds between two concepts represented by variables for which a statistical correlation is demonstrated, wherein variable values move together in the same direction (i.e. increased in one or presence of one correlates with an increase or presence of the other)." .
  biolink:preceded_by rdfs:label "preceded by - holds between two processes, where the other is completed before the one begins" .
  biolink:precedes rdfs:label "precedes - holds between two processes, where one completes before the other begins" .
  biolink:predisposes rdfs:label "predisposes - holds between two entities where exposure to one entity increases the chance of developing the other" .
  biolink:prevented_by rdfs:label "prevented by - holds between a potential outcome of which the likelihood was reduced by the application or use of an entity." .
  biolink:prevents rdfs:label "prevents - holds between an entity whose application or use reduces the likelihood of a potential outcome. Typically used to associate a chemical entity, exposure, activity, or medical intervention that can prevent the onset a disease or phenotypic feature." .
  biolink:produces rdfs:label "produces - holds between a material entity and a product that is generated through the intentional actions or functioning of the material entity" .
  biolink:regulates rdfs:label "regulates - A more specific form of affects, that implies the effect results from a biologically evolved control mechanism. Gene-affects-gene relationships will (almost) always involve regulation. Exogenous/environmental chemical-affects-gene relationships are not cases of regulation in this definition. Instead these would be captured using the 'affects' predicate, or possibly one of the 'interacts with' predicates depending on the nature of the interaction." .
  biolink:related_to rdfs:label "related to - A relationship that is asserted between two named things" .
  biolink:response_affected_by rdfs:label "response affected by - holds between two chemical entities where the susceptibility of a biological entity or system (e.g. an organism, cell, cellular component, macromolecular machine mixin, biological or pathological process) of one is affected by the action of the other." .
  biolink:similar_to rdfs:label "similar to - holds between an entity and some other entity with similar features." .
  biolink:target_for rdfs:label "target for - A gene is a target of a disease when its products are druggable and when a drug interaction with the gene product could have a therapeutic effect" .
  biolink:temporally_related_to rdfs:label "temporally related to - holds between two entities with a temporal relationship" .
  biolink:transcribed_from rdfs:label "transcribed from - x is transcribed from y if and only if x is synthesized from template y" .
  biolink:transcribed_to rdfs:label "transcribed to - inverse of transcribed from" .
  biolink:translates_to rdfs:label "translates to - x (amino acid chain/polypeptide) is the ribosomal translation of y (transcript) if and only if a ribosome reads y (transcript) through a series of triplet codon-amino acid adaptor activities (GO:0030533) and produces x (amino acid chain/polypeptide)" .
  biolink:translation_of rdfs:label "translation of - inverse of translates to" .
  biolink:treated_by rdfs:label "treated by - holds between a disease or phenotypic feature and a therapeutic process or chemical entity that is used to treat the condition" .
  biolink:treats rdfs:label "treats - holds between a therapeutic procedure or chemical entity and a disease or phenotypic feature that it is used to treat" .
  biolink:xenologous_to rdfs:label "xenologous to - a homology relationship characterized by an interspecies (horizontal) transfer since the common ancestor." .
}