@prefix biolink: <https://w3id.org/biolink/vocab/> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix this: <http://purl.org/np/RAYc78YuHdKgBOVrJnf7BUNafyCOw_5axCELtSvZx82bc> .
@prefix sub: <http://purl.org/np/RAYc78YuHdKgBOVrJnf7BUNafyCOw_5axCELtSvZx82bc#> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix nt: <https://w3id.org/np/o/ntemplate/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix orcid: <https://orcid.org/> .
@prefix nkg: <https://w3id.org/um/neurodkg/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix npx: <http://purl.org/nanopub/x/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:association rdf:object <https://identifiers.org/MONDO:0001780>;
    rdf:predicate biolink:treats;
    rdf:subject <https://go.drugbank.com/drugs/DB00193>;
    a rdf:Statement;
    rdfs:label "Off-label, the drug is useful for premature ejaculation and restless leg syndrome refractory to other medications. For the off-label use of tramadol for premature ejaculation, both sporadic and daily use is effective for the treatment of the condition. Patients indicate a preference for \"as needed\" therapy for premature ejaculation due to the lack of side effects compared to the daily use of tramadol.";
    biolink:association_type biolink:ChemicalToDiseaseOrPhenotypicFeatureAssociation;
    biolink:has_population_context sub:cohort;
    biolink:provided_by <https://w3id.org/um/NeuroDKG>;
    biolink:publications <https://pubmed.ncbi.nlm.nih.gov/33232099>;
    biolink:relation nkg:OffLabelIndication .
  
  sub:cohort rdfs:label "adults";
    biolink:category biolink:Cohort .
  
  <https://go.drugbank.com/drugs/DB00193> biolink:category biolink:Drug .
  
  <https://identifiers.org/MONDO:0001780> biolink:category biolink:Disease .
}

sub:provenance {
  sub:assertion prov:wasAttributedTo orcid:0000-0002-1468-3557 .
}

sub:pubinfo {
  sub:sig npx:hasAlgorithm "RSA";
    npx:hasPublicKey "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCODwZkXojpEKwk7Ldj2oPPfCstvqrcpgCaTLo235K7ht9C7E1GCkLvUuL2b4VWXJTcZx/hxgDauR8hUeYq/lS6tfTL9yFZsnfl+PWYDyz7vv6N+wJVx2LL8bO6ntCjcOzvW2t2WUeF12Sb6b3I6uOYP0N8iQKts1WasY/yEYKAHQIDAQAB";
    npx:hasSignature "Zbuyo49ppS7M7ugDdbV3h212z0uWI7wlupyh2FVkwRRfBrjVnZY82t8SGLhN6KXv3Fn3j6JH1G0iL0idqECv3jMnQa0EALs2b807eWb7LPZlAtTdOR80k1RtYEiSPGDrQJLcBSSDMJGqFCEivldZ8sqvw4y6YpX2YKWPSnIeoRI=";
    npx:hasSignatureTarget this: .
  
  this: dcterms:created "2021-05-01T10:34:54.019+02:00"^^xsd:dateTime;
    dcterms:creator orcid:0000-0002-1468-3557;
    nt:wasCreatedFromProvenanceTemplate <http://purl.org/np/RANwQa4ICWS5SOjw7gp99nBpXBasapwtZF1fIM3H2gYTM>;
    nt:wasCreatedFromPubinfoTemplate <http://purl.org/np/RAA2MfqdBCzmz9yVWjKLXNbyfBNcwsMmOqcNUxkk1maIM>;
    nt:wasCreatedFromTemplate <http://purl.org/np/RAZdZj78B6nKrP1Q00oFzsK07u7WdiY3sToz-H-H2nSgg> .
}