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tretinoin capsules are indicated for the induction of remission in patients with acute promyelocytic leukemia apl french american british fab classification m3 including the m3 variant characterized by the presence of the t 15 17 translocation and or the presence of the pml rari gene who are refractory to or who have relapsed from anthracycline chemotherapy or for whom anthracycline based chemotherapy is contraindicated tretinoin capsules are for the induction of remission only the optimal consolidation or maintenance regimens have not been defined but all patients should receive an accepted form of remission consolidation and or maintenance therapy for apl after completion of induction therapy with tretinoin capsules
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