@prefix orcid: <https://orcid.org/> .
@prefix this: <http://purl.org/np/RAp5_hKccJTnVTOd1ZeY3Usj1Nzm3fPCu7V0TRBfW7hq8> .
@prefix sub: <http://purl.org/np/RAp5_hKccJTnVTOd1ZeY3Usj1Nzm3fPCu7V0TRBfW7hq8#> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix ns2: <http://twoc-nlp-database-server-1:8555/solr/triples/select?fl=TRIPLE_UID,%20CORD_UID,%20SUBJECT,%20PREDICATE,%20WORDNET_SEMREL,%20%20OBJECT,%20PRED_POSITION,%20SUBJECT_CUIS,%20OBJECT_CUIS,%20UMLS_SEMREL,%20PRED_POSITION,%20PREDICATE-LEMMA&q=CORD_UID:wdxnfuun&rows=> .
@prefix ns1: <http://wordnet-rdf.princeton.edu/lemma/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix ns3: <http://twoc-nlp-database-server-1:8555/solr/triples/select?q=TRIPLE_UID:> .
@prefix npx: <http://purl.org/nanopub/x/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubInfo;
    a np:Nanopublication .
}

sub:assertion {
  <https://uts.nlm.nih.gov/uts/umls/concept/C0011816> ns1:integrate <https://uts.nlm.nih.gov/uts/umls/concept/C1280519> .
}

sub:provenance {
  sub:assertion prov:generatedAtTime "2021-12-16T19:29:41.598554"^^xsd:dateTime;
    prov:wasGeneratedBy "S&T TWOC project version 2" .
  
  sub:version prov:value "2"^^xsd:integer .
  
  rdf:OBJECT rdfs:label "into the final PK / PD model, \", where dexamethasone ( DEX ) exerted dexamethasone ( DEX ) s antitumor efficacy by inhibiting the proliferation of tumor cells\", enhanced dexamethasone ( DEX ) responses by decreasing the sensitivity parameter EC(50 )" .
  
  rdf:OBJECT-POSITION rdfs:label "102"^^xsd:integer .
  
  rdf:PREDICATE rdfs:label "integrated" .
  
  rdf:PREDICATE-POSITION rdfs:label "[154]" .
  
  rdf:SUBJECT rdfs:label "The PK model of dopamine D(2)-like receptor ( D2DR ) antagonist sulpiride ( SUL ) as well as that of dexamethasone ( DEX ) with a time-dependent clearance" .
  
  rdf:SUBJECT-POSITION rdfs:label "116"^^xsd:integer .
  
  rdfs:ABSTRACT-UID ns2:50 "wdxnfuun" .
  
  rdfs:SENTENCE rdfs:label "The PK model of dopamine D(2)-like receptor (D2DR) antagonist sulpiride (SUL) as well as that of dexamethasone (DEX) with a time-dependent clearance were integrated into the final PK/PD model both using Hill’s function, where dexamethasone (DEX) exerted dexamethasone (DEX)'s antitumor efficacy by inhibiting the proliferation of tumor cells, and dopamine D(2)-like receptor (D2DR) antagonist sulpiride (SUL) enhanced dexamethasone (DEX) responses by decreasing the sensitivity parameter EC(50)." .
  
  rdfs:TRIPLE-UID ns3:wdxnfuun-TRIPLE-ABSTRACT-10 "wdxnfuun-TRIPLE-ABSTRACT-10" .
  
  <https://uts.nlm.nih.gov/uts/umls/concept/C0011816> rdfs:label "dex" .
  
  <https://uts.nlm.nih.gov/uts/umls/concept/C1280519> rdfs:label "efficacy" .
}

sub:pubInfo {
  sub:assertion prov:wasDerivedFrom <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470835/> .
  
  sub:sig npx:hasAlgorithm "RSA";
    npx:hasPublicKey "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCSLeezU8JYlBsrgXOGXX4fxOq4oydsMzMK1CN0Rez2OEd2IYk18R4DetcZXwGhN3Pil7qcgNkiGvTirJXIo8zHl7jVehs19EdYtrttCKEaXRzWIr4LuCrfGedkvonEMWqR8e1GdQsLgEEyM50BD6Qw+srQt9ozcqf/9wG2MAMX9QIDAQAB";
    npx:hasSignature "HpsDjWtGVtwaAOcMLLKY04hLwN6pFhPN6+VbMlOaKXEHixfeMo6gSeuTXqAgaw8m31Ch8VnAsP5LEGZ+U6MMkvZp/a60EtcmQgyjfLG5tem4a+pJNe5hFIgGiitqwIAKmubYXS60/gfBox54Fcj8Q2j3ifwUL6R6na7zdjmxCzU=";
    npx:hasSignatureTarget this: .
  
  this: prov:generatedAtTime "2021-12-16T19:29:41.598554"^^xsd:dateTime;
    prov:wasAttributedTo orcid:0000-0002-8954-0470 .
}