@prefix nt: <
https://w3id.org/np/o/ntemplate/
> .
@prefix orcid: <
https://orcid.org/
> .
@prefix bl: <
https://w3id.org/biolink/vocab/
> .
@prefix nkg: <
https://w3id.org/um/neurodkg/
> .
@prefix this: <
http://purl.org/np/RApvz0KTvpeUh13pW3AT7Cqur78zw1641QohhEOSFHkyE
> .
@prefix sub: <
http://purl.org/np/RApvz0KTvpeUh13pW3AT7Cqur78zw1641QohhEOSFHkyE#
> .
@prefix np: <
http://www.nanopub.org/nschema#
> .
@prefix rdf: <
http://www.w3.org/1999/02/22-rdf-syntax-ns#
> .
@prefix xsd: <
http://www.w3.org/2001/XMLSchema#
> .
@prefix rdfs: <
http://www.w3.org/2000/01/rdf-schema#
> .
@prefix prov: <
http://www.w3.org/ns/prov#
> .
@prefix npx: <
http://purl.org/nanopub/x/
> .
sub:Head
{
this:
np:hasAssertion
sub:assertion
;
np:hasProvenance
sub:provenance
;
np:hasPublicationInfo
sub:pubInfo
;
a
np:Nanopublication
.
}
sub:assertion
{
sub:association
rdf:object
<
http://www.ebi.ac.uk/efo/EFO_0009854
> ;
rdf:predicate
bl:treats
;
rdf:subject
<
https://identifiers.org/DRUGBANK:DB01221
> ;
a
rdf:Statement
;
rdfs:label
"Off-label ketamine treatment has shown acute antidepressant effects that offer hope for patients with therapy-resistant depression. However, its potential for integration into treatment algorithms is controversial, not least because the evidence base for maintenance treatment with repeated ketamine administration is currently weak. Ketamine is also a drug of misuse, which has raised concerns regarding the target population." ;
bl:has_population_context
sub:context
;
bl:provided_by
<
https://w3id.org/um/NeuroDKG
> ;
bl:publications
<
https://pubmed.ncbi.nlm.nih.gov/30202601
> ;
bl:relation
nkg:OffLabelIndication
.
sub:context
a
bl:Cohort
;
rdfs:label
"adults" .
<
http://www.ebi.ac.uk/efo/EFO_0009854
>
a
bl:Disease
.
<
https://identifiers.org/DRUGBANK:DB01221
>
a
bl:Drug
.
}
sub:provenance
{
sub:assertion
prov:generatedAtTime
"2021-08-25T12:27:36.572421"^^
xsd:dateTime
.
}
sub:pubInfo
{
sub:sig
npx:hasAlgorithm
"RSA" ;
npx:hasPublicKey
"MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCamPJb4SzqpLXn//XJ5dlVfzz6QI+RPmiJTLXF/by2JR7sHMKRsCQDFsYMlq8zGHghOIkjRP9dpLZUtZzUcHt3MXiFKEPo8eGzUe9p+JXKFC8xxkJr94z2vq6IdMf71Iu1GH8SeDAKt/DgYO4zNaw8VuXvxnZRewKZSA+u8zWPVwIDAQAB" ;
npx:hasSignature
"JYAxjIqL7BG7M5lHqJBgOtGUQCkALX8RKI5cah0jh8nFeY8dlRQrcxOUL7NJls2wIxqhihqFHo/RKAYJAj40/eI6z80wiwvs7jWjk8TFyEvtshmiifbYXEv8Vz0Dl1mM+ZTMxpVK8EoJxOQVRDPr4To6lNQ40SzcyHM3TWn+Hs8=" ;
npx:hasSignatureTarget
this:
.
this:
prov:generatedAtTime
"2021-08-25T12:27:36.572421"^^
xsd:dateTime
;
prov:wasAttributedTo
orcid:0000-0002-7641-6446
;
nt:wasCreatedFromTemplate
<
http://purl.org/np/RAhNHZw6Urw_Mccs4qy6Ws3C9CRuaHpQx8AwuApbWkqnY
> .
}