http://purl.org/np/RAqCvrlrWXBYXGaSibHkaus6jdDpT0Z-AkWBsBOFX_FFA#Head http://purl.org/np/RAqCvrlrWXBYXGaSibHkaus6jdDpT0Z-AkWBsBOFX_FFA http://www.nanopub.org/nschema#hasAssertion http://purl.org/np/RAqCvrlrWXBYXGaSibHkaus6jdDpT0Z-AkWBsBOFX_FFA#assertion http://purl.org/np/RAqCvrlrWXBYXGaSibHkaus6jdDpT0Z-AkWBsBOFX_FFA http://www.nanopub.org/nschema#hasProvenance http://purl.org/np/RAqCvrlrWXBYXGaSibHkaus6jdDpT0Z-AkWBsBOFX_FFA#provenance http://purl.org/np/RAqCvrlrWXBYXGaSibHkaus6jdDpT0Z-AkWBsBOFX_FFA http://www.nanopub.org/nschema#hasPublicationInfo http://purl.org/np/RAqCvrlrWXBYXGaSibHkaus6jdDpT0Z-AkWBsBOFX_FFA#pubInfo http://purl.org/np/RAqCvrlrWXBYXGaSibHkaus6jdDpT0Z-AkWBsBOFX_FFA http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://purl.org/np/RAqCvrlrWXBYXGaSibHkaus6jdDpT0Z-AkWBsBOFX_FFA#assertion http://purl.obolibrary.org/obo/MONDO_0100081 http://www.w3.org/1999/02/22-rdf-syntax-ns#type https://w3id.org/biolink/vocab/Disease http://purl.org/np/RAqCvrlrWXBYXGaSibHkaus6jdDpT0Z-AkWBsBOFX_FFA#association http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://purl.obolibrary.org/obo/MONDO_0100081 http://purl.org/np/RAqCvrlrWXBYXGaSibHkaus6jdDpT0Z-AkWBsBOFX_FFA#association http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate https://w3id.org/biolink/vocab/treats http://purl.org/np/RAqCvrlrWXBYXGaSibHkaus6jdDpT0Z-AkWBsBOFX_FFA#association http://www.w3.org/1999/02/22-rdf-syntax-ns#subject https://identifiers.org/DRUGBANK:DB00370 http://purl.org/np/RAqCvrlrWXBYXGaSibHkaus6jdDpT0Z-AkWBsBOFX_FFA#association http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://purl.org/np/RAqCvrlrWXBYXGaSibHkaus6jdDpT0Z-AkWBsBOFX_FFA#association http://www.w3.org/2000/01/rdf-schema#label Among TCAs, doxepin (sinequan) appears to be best suited for managing insomnia in healthy adults. Doxepin works as a selective antagonist to H(1) receptors, which promote the initiation and maintenance of sleep (Owen, 2009) (Table 2 contains information on trazodone and mirtazapine). Ultra-low doses of this drug (< 6 mg per day) significantly improve and sustain both maintenance and duration of sleep (Rojas-Fernandez and Chen, 2014; Weber et al., 2010). Another frequently prescribed TCA is amitriptyline, which as a long-term option is found to be effective for patients with ongoing sleep problems (Everitt et al., 2014; Pagel and Parnes, 2001). http://purl.org/np/RAqCvrlrWXBYXGaSibHkaus6jdDpT0Z-AkWBsBOFX_FFA#association https://w3id.org/biolink/vocab/has_population_context http://purl.org/np/RAqCvrlrWXBYXGaSibHkaus6jdDpT0Z-AkWBsBOFX_FFA#context http://purl.org/np/RAqCvrlrWXBYXGaSibHkaus6jdDpT0Z-AkWBsBOFX_FFA#association https://w3id.org/biolink/vocab/provided_by https://w3id.org/um/NeuroDKG http://purl.org/np/RAqCvrlrWXBYXGaSibHkaus6jdDpT0Z-AkWBsBOFX_FFA#association https://w3id.org/biolink/vocab/publications https://pubmed.ncbi.nlm.nih.gov/31622593 http://purl.org/np/RAqCvrlrWXBYXGaSibHkaus6jdDpT0Z-AkWBsBOFX_FFA#association https://w3id.org/biolink/vocab/relation https://w3id.org/um/neurodkg/OffLabelIndication http://purl.org/np/RAqCvrlrWXBYXGaSibHkaus6jdDpT0Z-AkWBsBOFX_FFA#context http://www.w3.org/1999/02/22-rdf-syntax-ns#type https://w3id.org/biolink/vocab/Cohort http://purl.org/np/RAqCvrlrWXBYXGaSibHkaus6jdDpT0Z-AkWBsBOFX_FFA#context http://www.w3.org/2000/01/rdf-schema#label Adults https://identifiers.org/DRUGBANK:DB00370 http://www.w3.org/1999/02/22-rdf-syntax-ns#type https://w3id.org/biolink/vocab/Drug http://purl.org/np/RAqCvrlrWXBYXGaSibHkaus6jdDpT0Z-AkWBsBOFX_FFA#provenance http://purl.org/np/RAqCvrlrWXBYXGaSibHkaus6jdDpT0Z-AkWBsBOFX_FFA#assertion http://www.w3.org/ns/prov#generatedAtTime 2021-08-16T20:58:21.683895 http://purl.org/np/RAqCvrlrWXBYXGaSibHkaus6jdDpT0Z-AkWBsBOFX_FFA#pubInfo http://purl.org/np/RAqCvrlrWXBYXGaSibHkaus6jdDpT0Z-AkWBsBOFX_FFA#sig http://purl.org/nanopub/x/hasAlgorithm RSA http://purl.org/np/RAqCvrlrWXBYXGaSibHkaus6jdDpT0Z-AkWBsBOFX_FFA#sig http://purl.org/nanopub/x/hasPublicKey MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCamPJb4SzqpLXn//XJ5dlVfzz6QI+RPmiJTLXF/by2JR7sHMKRsCQDFsYMlq8zGHghOIkjRP9dpLZUtZzUcHt3MXiFKEPo8eGzUe9p+JXKFC8xxkJr94z2vq6IdMf71Iu1GH8SeDAKt/DgYO4zNaw8VuXvxnZRewKZSA+u8zWPVwIDAQAB http://purl.org/np/RAqCvrlrWXBYXGaSibHkaus6jdDpT0Z-AkWBsBOFX_FFA#sig http://purl.org/nanopub/x/hasSignature QuD/6CVjfKGi5a6X661Abu1gVTwMQ0XkPK5Q6yEDBoPapb1EcKGnEaZT0ESI23TxyUt2i7O3cLR8JxyP0tZHytYhHG6T0neYZIkNi6E8mdUgmeGadsvEKPwxSc1ovY8rORS2PybzJ3JxpLZwcNOGJOi8wBqHlc6AboPIXy+Hd6Q= http://purl.org/np/RAqCvrlrWXBYXGaSibHkaus6jdDpT0Z-AkWBsBOFX_FFA#sig http://purl.org/nanopub/x/hasSignatureTarget http://purl.org/np/RAqCvrlrWXBYXGaSibHkaus6jdDpT0Z-AkWBsBOFX_FFA http://purl.org/np/RAqCvrlrWXBYXGaSibHkaus6jdDpT0Z-AkWBsBOFX_FFA http://www.w3.org/ns/prov#generatedAtTime 2021-08-16T20:58:21.683895 http://purl.org/np/RAqCvrlrWXBYXGaSibHkaus6jdDpT0Z-AkWBsBOFX_FFA http://www.w3.org/ns/prov#wasAttributedTo https://orcid.org/0000-0002-7641-6446 http://purl.org/np/RAqCvrlrWXBYXGaSibHkaus6jdDpT0Z-AkWBsBOFX_FFA https://w3id.org/np/o/ntemplate/wasCreatedFromTemplate http://purl.org/np/RAhNHZw6Urw_Mccs4qy6Ws3C9CRuaHpQx8AwuApbWkqnY