@prefix nkg: .
@prefix nt: .
@prefix orcid: .
@prefix bl: .
@prefix this: .
@prefix sub: .
@prefix np: .
@prefix rdf: .
@prefix xsd: .
@prefix rdfs: .
@prefix prov: .
@prefix npx: .
sub:Head {
this: np:hasAssertion sub:assertion;
np:hasProvenance sub:provenance;
np:hasPublicationInfo sub:pubInfo;
a np:Nanopublication .
}
sub:assertion {
a bl:Disease .
sub:association rdf:object ;
rdf:predicate bl:treats;
rdf:subject ;
a rdf:Statement;
rdfs:label "Escitalopram showed favorable pharmacokinetics and good tolerability. It is the most 5-HT-selective among SSRIs, with little or no affinity for other transmitter transporters or receptors [59]. Compared to other SSRIs, escitalopram may have weak or minimal interactions with the cytochrome P450 system [60, 61]. In a randomized, double-blind, placebo-controlled 24-week trial in OCD, escitalopram (20 mg/day) was associated with an increase in response rate compared to placebo after 12 weeks. Other placebo-controlled studies consistently showed escitalopram-related treatment response [25, 30]. 20 mg/day escitalopram has also been associated with better OCD symptom remission compared to 40 mg/day paroxetine or placebo at week 12 [30]. Three different escitalopram dosages (5, 10, and 20 mg/day) were compared with a fixed, 20 mg/day dose of paroxetine in a 12-week study, in which escitalopram showed both greater efficacy and better tolerability [62].";
bl:has_population_context sub:context;
bl:provided_by ;
bl:publications ;
bl:relation nkg:OffLabelIndication .
sub:context a bl:Cohort;
rdfs:label "adults" .
a bl:Drug .
}
sub:provenance {
sub:assertion prov:generatedAtTime "2021-08-25T14:52:33.344024"^^xsd:dateTime .
}
sub:pubInfo {
sub:sig npx:hasAlgorithm "RSA";
npx:hasPublicKey "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCamPJb4SzqpLXn//XJ5dlVfzz6QI+RPmiJTLXF/by2JR7sHMKRsCQDFsYMlq8zGHghOIkjRP9dpLZUtZzUcHt3MXiFKEPo8eGzUe9p+JXKFC8xxkJr94z2vq6IdMf71Iu1GH8SeDAKt/DgYO4zNaw8VuXvxnZRewKZSA+u8zWPVwIDAQAB";
npx:hasSignature "ZhTHDwytjnomCNC0hmlbG+CJfBrD7z/xB70O6L0Rn+y7MK9gjicCRkdI3xpYiud7kWlvm4UHyvpn9dsgkarP/7Y0fC23KOQw5gPsRvvruPEeKojbMtMJfRvst7jbe4FTmoO+U002ZFOkNkL0odAoFPcMAhTnGvoIyOThakDUbow=";
npx:hasSignatureTarget this: .
this: prov:generatedAtTime "2021-08-25T14:52:33.344024"^^xsd:dateTime;
prov:wasAttributedTo orcid:0000-0002-7641-6446;
nt:wasCreatedFromTemplate .
}