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[Keeping in view the fact that the most pathognomonic feature of Alzheimer's disease is the abnormal processing of neuronal cell membrane amyloid precursor protein accompanied by significantly elevated human serum and CSF levels of 24-hydroxycholesterol recognised widely as the specific endogenous ligand of Liver X receptor (LXR-?), the present study was addressed to explore the epigenomic-pathway (if any) that connects LXR-? activation with the genes recognised to be involved in the regulation of aberrant Abeta production leading to the generation of toxic and inflammatory mediators responsible for neuronal death.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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