@prefix dc1: <
http://purl.org/dc/terms/
> .
@prefix this: <
http://purl.org/np/RA9MZGq_4-yhNS3GpBmwGp9EzDE_UFZyERMiuoU1CUxiE
> .
@prefix sub: <
http://purl.org/np/RA9MZGq_4-yhNS3GpBmwGp9EzDE_UFZyERMiuoU1CUxiE#
> .
@prefix schema: <
https://schema.org/
> .
@prefix np: <
http://www.nanopub.org/nschema#
> .
@prefix rdf: <
http://www.w3.org/1999/02/22-rdf-syntax-ns#
> .
@prefix nt: <
https://w3id.org/np/o/ntemplate/
> .
@prefix xsd: <
http://www.w3.org/2001/XMLSchema#
> .
@prefix rdfs: <
http://www.w3.org/2000/01/rdf-schema#
> .
@prefix orcid: <
https://orcid.org/
> .
@prefix bl: <
https://w3id.org/biolink/vocab/
> .
@prefix prov: <
http://www.w3.org/ns/prov#
> .
@prefix npx: <
http://purl.org/nanopub/x/
> .
sub:Head
{
this:
np:hasAssertion
sub:assertion
;
np:hasProvenance
sub:provenance
;
np:hasPublicationInfo
sub:pubinfo
;
a
np:Nanopublication
.
}
sub:assertion
{
<
http://purl.obolibrary.org/obo/DOID_893
>
bl:category
bl:Disease
.
sub:association
rdf:object
<
http://purl.obolibrary.org/obo/DOID_893
> ;
rdf:predicate
bl:treats
;
rdf:subject
<
https://identifiers.org/drugbank:DB06824
> ;
a
rdf:Statement
;
rdfs:label
"trientine hydrochloride capsule is indicated in the treatment of patients with wilson s disease who are intolerant of penicillamine clinical experience with trientine hydrochloride capsule is limited and alternate dosing regimens have not been well characterized all endpoints in determining an individual patient s dose have not been well defined trientine hydrochloride capsule and penicillamine cannot be considered interchangeable trientine hydrochloride capsule should be used when continued treatment with penicillamine is no longer possible because of intolerable or life endangering side effects unlike penicillamine trientine hydrochloride capsule is not recommended in cystinuria or rheumatoid arthritis the absence of a sulfhydryl moiety renders it incapable of binding cystine and therefore it is of no use in cystinuria in 15 patients with rheumatoid arthritis trientine hydrochloride capsule was reported not to be effective in improving any clinical or biochemical parameter after 12 weeks of treatment trientine hydrochloride capsule is not indicated for treatment of biliary cirrhosis" ;
bl:association_type
bl:ChemicalToDiseaseOrPhenotypicFeatureAssociation
;
bl:provided_by
<
https://w3id.org/um/NeuroDKG
> ;
bl:relation
schema:TreatmentIndication
.
<
https://identifiers.org/drugbank:DB06824
>
bl:category
bl:Drug
.
}
sub:provenance
{
sub:assertion
prov:wasAttributedTo
orcid:0000-0002-1468-3557
.
}
sub:pubinfo
{
sub:sig
npx:hasAlgorithm
"RSA" ;
npx:hasPublicKey
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npx:hasSignature
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npx:hasSignatureTarget
this:
.
this:
dc1:created
"2021-06-13T12:48:34.141+02:00"^^
xsd:dateTime
;
dc1:creator
orcid:0000-0002-1468-3557
;
nt:wasCreatedFromProvenanceTemplate
<
http://purl.org/np/RANwQa4ICWS5SOjw7gp99nBpXBasapwtZF1fIM3H2gYTM
> ;
nt:wasCreatedFromPubinfoTemplate
<
http://purl.org/np/RAA2MfqdBCzmz9yVWjKLXNbyfBNcwsMmOqcNUxkk1maIM
> ;
nt:wasCreatedFromTemplate
<
http://purl.org/np/RAManV5GZI01JKzW_IPcfOXoiFTcZMmsV7qTCLkdzr4Gs
> .
}