sub:assertion {
  <http://purl.obolibrary.org/obo/DOID_0060224> bl:category bl:Disease .
  sub:association rdf:object <http://purl.obolibrary.org/obo/DOID_0060224> ;
    rdf:predicate bl:treats ;
    rdf:subject <https://identifiers.org/drugbank:DB00571> ;
    a rdf:Statement ;
    rdfs:label "intravenous administration is usually reserved for life threatening arrhythmias or those occurring under anesthesia 1 supraventricular arrhythmia intravenous propranolol is indicated for the short term treatment of supraventricular tachycardia including wolff parkinson white syndrome and thyrotoxicosis to decrease ventricular rate use in patients with atrial flutter or atrial fibrillation should be reserved for arrythmias unresponsive to standard therapy or when more prolonged control is required reversion to normal sinus rhythm has occasionally been observed predominantly in patients with sinus or atrial tachycardia 2 ventricular tachycardias with the exception of those induced by catecholamines or digitalis propranolol is not the drug of first choice in critical situations when cardioversion techniques or other drugs are not indicated or are not effective propranolol may be considered if after consideration of the risks involved propranolol is used it should be given intravenously in low dosage and very slowly as the failing heart requires some sympathetic drive for maintenance of myocardial tone see dosage and administration some patients may respond with complete reversion to normal sinus rhythm but reduction in ventricular rate is more likely ventricular arrhythmias do not respond to propranolol as predictably as do the supraventricular arrhythmias intravenous propranolol is indicated for the treatment of persistent premature ventricular extrasystoles that impair the well being of the patient and do not respond to conventional measures 3 tachyarrhythmias of digitalis intoxication intravenous propranolol is indicated to control ventricular rate in life threatening digitalis induced arrhythmias severe bradycardia may occur see overdosage 4 resistant tachyarrhythmias due to excessive catecholamine action during anesthesia intravenous propranolol is indicated to abolish tachyarrhythmias due to excessive catecholamine action during anesthesia when other measures fail these arrhythmias may arise because of release of endogenous catecholamines or administration of catecholamines all general inhalation anesthetics produce some degree of myocardial depression therefore when propranolol is used to treat arrhythmias during anesthesia it should be used with extreme caution usually with constant monitoring of the ecg and central venous pressure see warnings" ;
    bl:association_type bl:ChemicalToDiseaseOrPhenotypicFeatureAssociation ;
    bl:provided_by <https://w3id.org/um/NeuroDKG> ;
    bl:relation nkg:SymptomaticReliefIndication .
  <https://identifiers.org/drugbank:DB00571> bl:category bl:Drug .
}