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[Plasma cell-free DNA, as quantified by polymerase chain reaction amplification of the ?-globin and human telomerase reverse transcriptase genes, is increased in sickle cell disease patients in vaso-occlusive crisis and in steady state compared with individuals with sickle cell trait and healthy controls, and may be used as a tool to diagnose and monitor the sickle cell crisis and differentiate post-packed red cell transfusion sickle cell disease patients from individuals with sickle cell trait.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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