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(HIF-1?) (1.54 � 0.13 fold in PC-3, p = 0.002, 1.62 � 0.12 fold in LNCaP, p = 0.001) and HIF-1? (1.67 � 0.23 fold in PC-3, p = 0.007; 1.75 � 0.26 fold in LNCaP, p=0.008) were upregulated in prostate cancer bone metastasis PC-3 and LNCaP cell lines in response to hypoxia, and revealed that the regulation of VEGF by HIF-1? and HIF-1? was possibly mediated by the activation of phosphatidylinositol 3-kinase pathway.]. 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