@prefix ncit: <http://purl.obolibrary.org/obo/NCIT_> .
@prefix bl: <https://w3id.org/biolink/vocab/> .
@prefix nkg: <https://w3id.org/um/neurodkg/> .
@prefix nt: <https://w3id.org/np/o/ntemplate/> .
@prefix orcid: <https://orcid.org/> .
@prefix this: <http://purl.org/np/RAEI4CJNinUGpNrUW6EqtFh2xVekTraB2Hjyf-6v9LjJY> .
@prefix sub: <http://purl.org/np/RAEI4CJNinUGpNrUW6EqtFh2xVekTraB2Hjyf-6v9LjJY#> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix npx: <http://purl.org/nanopub/x/> .
sub:Head {
   this: np:hasAssertion sub:assertion ;
    np:hasProvenance sub:provenance ;
    np:hasPublicationInfo sub:pubInfo ;
    a np:Nanopublication .
}
sub:assertion {
   ncit:C17427 a bl:Disease .
  sub:association rdf:object ncit:C17427 ;
    rdf:predicate bl:treats ;
    rdf:subject <https://identifiers.org/DRUGBANK:DB00540> ;
    a rdf:Statement ;
    rdfs:label "Drugs from all five classes of antidepressants have been investigated for use as smoking cessation aids (Shoaib and Buhidma, 2018). The second generation TCA nortriptyline is regarded as the most promising alternative to bupropion. This antidepressant mainly inhibits noradrenaline and serotonin transporters (Kripke, 2005). Antidepressants of the SSRI category are not effective, however, suggesting that serotonin does not play the main role in smoking addiction (Hughes et al., 2014)." ;
    bl:has_population_context sub:context ;
    bl:provided_by <https://w3id.org/um/NeuroDKG> ;
    bl:publications <https://pubmed.ncbi.nlm.nih.gov/31622593> ;
    bl:relation nkg:OffLabelIndication .
  sub:context a bl:Cohort ;
    rdfs:label "Adults" .
  <https://identifiers.org/DRUGBANK:DB00540> a bl:Drug .
}
sub:provenance {
   sub:assertion prov:generatedAtTime "2021-08-16T20:58:15.534653"^^xsd:dateTime .
}
sub:pubInfo {
   sub:sig npx:hasAlgorithm "RSA" ;
    npx:hasPublicKey "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCamPJb4SzqpLXn//XJ5dlVfzz6QI+RPmiJTLXF/by2JR7sHMKRsCQDFsYMlq8zGHghOIkjRP9dpLZUtZzUcHt3MXiFKEPo8eGzUe9p+JXKFC8xxkJr94z2vq6IdMf71Iu1GH8SeDAKt/DgYO4zNaw8VuXvxnZRewKZSA+u8zWPVwIDAQAB" ;
    npx:hasSignature "A3QZQfsjefHmI0eO3g9ldlr5aht9whHtbWCcG6vPrNeaIGsua9F2TgBntvscotJTOVHKYYjQQiPrKKvN6xZW5YI5Qi364CL6kpCcB8eOl1eI/Bj+yndQxv0ArFvqikrsOTJdtQ1MdJPmdV1/ciMQq3wwIDbXNBflvrqc7Nyxre8=" ;
    npx:hasSignatureTarget this: .
  this: prov:generatedAtTime "2021-08-16T20:58:15.534653"^^xsd:dateTime ;
    prov:wasAttributedTo orcid:0000-0002-7641-6446 ;
    nt:wasCreatedFromTemplate <http://purl.org/np/RAhNHZw6Urw_Mccs4qy6Ws3C9CRuaHpQx8AwuApbWkqnY> .
}