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The main objective of this study is to evaluate the Shyft modelling framework in its ability to simulate main water balance components, especially discharge, in the specific conditions of the Budhi-Gandaki catchment with scarce data and extreme topography. • Is the model able to capture precipitation variations on the leeward and windward sides of the catchment, and predict discharge adequately? • How sensitive the model is to the forcings, spatial representation (grid or triangular- irregular networks) and scales? References: Bookhagen, B. & Burbank, D. W. (2010), ‘Toward a complete himalayan hydrological budget: Spatiotemporal distribution of snowmelt and rainfall and their impact on river discharge’, Journal of Geophysical Research: Earth Surface 115(F3). Ménégoz, M., Gallée, H. & Jacobi, H. 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