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[Furthermore, inhibition of G(i) signaling with pertussis toxin restores cardiac function in heart failure associated with increased ?(2)AR to G(i) coupling induced by removing PKA phosphorylation of the receptor and in GRK2 transgenic mice, indicating that enhanced phosphorylation of ?(2)AR by GRK and resultant increase in G(i)-biased ?(2)AR signaling play an important role in the development of heart failure.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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