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A comprehensive molecular framework of the disease is needed to better understand its pathological mechanisms, and to design successful treatments able to slow down and stop the impressive pace of the outbreak and harsh clinical symptomatology, possibly via the use of readily available, off-the-shelf drugs. This work engages in providing a wider picture of the human molecular landscape of the SARS-CoV-2 infection via a network medicine approach as the ground for a drug repurposing strategy. Grounding on prior knowledge such as experimentally validated host proteins known to be viral interactors, tissue-specific gene expression data, and using network analysis techniques such as network propagation and connectivity significance, the host molecular reaction network to the viral invasion is explored and exploited to infer and prioritize candidate target genes, and finally to propose drugs to be repurposed for the treatment of COVID-19. Ranks of potential target genes have been obtained for coherent groups of tissues/organs, potential and distinct sites of interaction between the virus and the organism. The normalization and the aggregation of the different scores allowed to define a preliminary, restricted list of genes candidates as pharmacological targets for drug repurposing, with the aim of contrasting different phases of the virus infection and viral replication cycle. https://w3id.org/ro-id/d8e686b6-199a-4296-88fa-3c03cdb5a4c1/ http://schema.org/encodingFormat application/ld+json https://w3id.org/ro-id/d8e686b6-199a-4296-88fa-3c03cdb5a4c1/ http://schema.org/hasPart https://w3id.org/ro-id/d8e686b6-199a-4296-88fa-3c03cdb5a4c1/resources/424605bc-3aaa-4d60-b516-8c57721e8c90 https://w3id.org/ro-id/d8e686b6-199a-4296-88fa-3c03cdb5a4c1/ http://schema.org/identifier https://w3id.org/ro-id/d8e686b6-199a-4296-88fa-3c03cdb5a4c1 https://w3id.org/ro-id/d8e686b6-199a-4296-88fa-3c03cdb5a4c1/ http://schema.org/license https://choosealicense.com/no-permission/ https://w3id.org/ro-id/d8e686b6-199a-4296-88fa-3c03cdb5a4c1/ http://schema.org/name Designing a Network Proximity-Based Drug Repurposing Strategy for COVID-19 https://w3id.org/ro-id/d8e686b6-199a-4296-88fa-3c03cdb5a4c1/ http://w3id.org/ro-id/rohub/model#creation_mode MANUAL https://w3id.org/ro-id/d8e686b6-199a-4296-88fa-3c03cdb5a4c1/ http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://purl.org/wf4ever/ro#ResearchObject https://w3id.org/ro-id/d8e686b6-199a-4296-88fa-3c03cdb5a4c1/ http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://purl.org/wf4ever/roevo#LiveRO https://w3id.org/ro-id/d8e686b6-199a-4296-88fa-3c03cdb5a4c1/ http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://schema.org/Dataset https://w3id.org/ro-id/d8e686b6-199a-4296-88fa-3c03cdb5a4c1/ http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://w3id.org/ro/earth-science#BibliographyResearchObject https://w3id.org/ro-id/d8e686b6-199a-4296-88fa-3c03cdb5a4c1/ http://www.w3.org/1999/02/22-rdf-syntax-ns#type https://w3id.org/ro/terms/earth-science#BibliographyResearchObject https://w3id.org/ro-id/d8e686b6-199a-4296-88fa-3c03cdb5a4c1/ https://www.w3.org/ns/iana/link-relations/relation#cite-as Foglini, Federica. "Designing a Network Proximity-Based Drug Repurposing Strategy for COVID-19." ROHub. 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A comprehensive molecular framework of the disease is needed to better understand its pathological mechanisms, and to design successful treatments able to slow down and stop the impressive pace of the outbreak and harsh clinical symptomatology, possibly via the use of readily available, off-the-shelf drugs. This work engages in providing a wider picture of the human molecular landscape of the SARS-CoV-2 infection via a network medicine approach as the ground for a drug repurposing strategy. Grounding on prior knowledge such as experimentally validated host proteins known to be viral interactors, tissue-specific gene expression data, and using network analysis techniques such as network propagation and connectivity significance, the host molecular reaction network to the viral invasion is explored and exploited to infer and prioritize candidate target genes, and finally to propose drugs to be repurposed for the treatment of COVID-19. Ranks of potential target genes have been obtained for coherent groups of tissues/organs, potential and distinct sites of interaction between the virus and the organism. 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