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[The variant proximal to NF?B1 controls signaling responses by altering the expression of NF?B itself, with the GG risk genotype expressing 20-fold more p50 NF?B and diminished expression of the negative regulators of the NF?B pathway: TNF?-induced protein 3 (TNFAIP3), B cell leukemia 3 (BCL3), and cellular inhibitor of apoptosis 1 (CIAP1).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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