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Lockdown during COVID-19 pandemics substantially cleaned the air. The objective of this is to assess the effects of air cleaning due to lockdown on stress echocardiography (SE) results. We enrolled 19 patients with chronic coronary artery disease and/or heart failure referred to SE (semi-supine bicycle exercise, n = 8, or dipyridamole, n = 11). Before and soon after lockdown, we assessed regional wall motion abnormalities (abnormal value: worsening of >= 2 segments), B-lines (a sign of pulmonary congestion, 4-site simplified scan, abnormal value >= 2), and coronary flow velocity reserve in left anterior descending artery (CFVR, abnormal value < 2.0). Local air quality indicators (same day of SE) of fine particulate matter (PM2.5) and nitrogen dioxide (NO2) were obtained from publicly available data sets of the regional authority of environmental protection. After lockdown, NO2 concentration decreased from 19 +/- 10 to 10 +/- 4 mu g/m(3) (p = 0.006). After lockdown, abnormal responses remained unchanged for ischemia (21% vs 16%, p = ns) and decreased for B-lines (42% vs 5%, p = 0.008) and CFVR (84 vs 42%, p = 0.007). Changes in coronary flow velocity reserve (CFVR) were correlated to same-day variations in NO2 (r = -0.578, p = 0.010) and preceding 30-day changes in PM2.5 (r = -0.518, p = 0.023). After lockdown, air cleaning was associated with a beneficial effect on coronary small vessel dysfunction and alveolar-capillary barrier distress mirrored by improvement of CFVR and B-lines during SE in vulnerable patients. Identifier: NCT 030.49995 https://w3id.org/ro-id/a6a75c2b-d935-4b65-be9f-4c8d6870461c/ http://schema.org/encodingFormat application/ld+json https://w3id.org/ro-id/a6a75c2b-d935-4b65-be9f-4c8d6870461c/ http://schema.org/hasPart https://w3id.org/ro-id/a6a75c2b-d935-4b65-be9f-4c8d6870461c/resources/fa5ddea5-9e02-4869-9a66-97c0a6cbc412 https://w3id.org/ro-id/a6a75c2b-d935-4b65-be9f-4c8d6870461c/ http://schema.org/identifier https://w3id.org/ro-id/a6a75c2b-d935-4b65-be9f-4c8d6870461c https://w3id.org/ro-id/a6a75c2b-d935-4b65-be9f-4c8d6870461c/ http://schema.org/license https://choosealicense.com/no-permission/ https://w3id.org/ro-id/a6a75c2b-d935-4b65-be9f-4c8d6870461c/ http://schema.org/name The effects of lockdown-induced air quality changes on the results of cardiac functional stress testing in coronary artery disease and heart failure patients https://w3id.org/ro-id/a6a75c2b-d935-4b65-be9f-4c8d6870461c/ http://w3id.org/ro-id/rohub/model#creation_mode MANUAL https://w3id.org/ro-id/a6a75c2b-d935-4b65-be9f-4c8d6870461c/ http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://purl.org/wf4ever/ro#ResearchObject https://w3id.org/ro-id/a6a75c2b-d935-4b65-be9f-4c8d6870461c/ http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://purl.org/wf4ever/roevo#LiveRO https://w3id.org/ro-id/a6a75c2b-d935-4b65-be9f-4c8d6870461c/ http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://schema.org/Dataset https://w3id.org/ro-id/a6a75c2b-d935-4b65-be9f-4c8d6870461c/ http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://w3id.org/ro/earth-science#BibliographyResearchObject https://w3id.org/ro-id/a6a75c2b-d935-4b65-be9f-4c8d6870461c/ http://www.w3.org/1999/02/22-rdf-syntax-ns#type https://w3id.org/ro/terms/earth-science#BibliographyResearchObject https://w3id.org/ro-id/a6a75c2b-d935-4b65-be9f-4c8d6870461c/ https://www.w3.org/ns/iana/link-relations/relation#cite-as Foglini, Federica. "The effects of lockdown-induced air quality changes on the results of cardiac functional stress testing in coronary artery disease and heart failure patients." ROHub. Dec 10 ,2021. https://w3id.org/ro-id/a6a75c2b-d935-4b65-be9f-4c8d6870461c. https://w3id.org/ro-id/a6a75c2b-d935-4b65-be9f-4c8d6870461c/resources/fa5ddea5-9e02-4869-9a66-97c0a6cbc412 http://schema.org/author mailto:service-account-generation-service https://w3id.org/ro-id/a6a75c2b-d935-4b65-be9f-4c8d6870461c/resources/fa5ddea5-9e02-4869-9a66-97c0a6cbc412 http://schema.org/contentSize 253 https://w3id.org/ro-id/a6a75c2b-d935-4b65-be9f-4c8d6870461c/resources/fa5ddea5-9e02-4869-9a66-97c0a6cbc412 http://schema.org/contentUrl https://api.rohub.org/api/resources/fa5ddea5-9e02-4869-9a66-97c0a6cbc412/download/ https://w3id.org/ro-id/a6a75c2b-d935-4b65-be9f-4c8d6870461c/resources/fa5ddea5-9e02-4869-9a66-97c0a6cbc412 http://schema.org/creator mailto:service-account-generation-service https://w3id.org/ro-id/a6a75c2b-d935-4b65-be9f-4c8d6870461c/resources/fa5ddea5-9e02-4869-9a66-97c0a6cbc412 http://schema.org/dateCreated 2021-12-10 09:58:05.576420+00:00 https://w3id.org/ro-id/a6a75c2b-d935-4b65-be9f-4c8d6870461c/resources/fa5ddea5-9e02-4869-9a66-97c0a6cbc412 http://schema.org/dateModified 2021-12-10 09:58:05.578099+00:00 https://w3id.org/ro-id/a6a75c2b-d935-4b65-be9f-4c8d6870461c/resources/fa5ddea5-9e02-4869-9a66-97c0a6cbc412 http://schema.org/description In vulnerable subjects, the increase in air pollution worsens the signs of myocardial ischemia. Lockdown during COVID-19 pandemics substantially cleaned the air. The objective of this is to assess the effects of air cleaning due to lockdown on stress echocardiography (SE) results. We enrolled 19 patients with chronic coronary artery disease and/or heart failure referred to SE (semi-supine bicycle exercise, n = 8, or dipyridamole, n = 11). Before and soon after lockdown, we assessed regional wall motion abnormalities (abnormal value: worsening of >= 2 segments), B-lines (a sign of pulmonary congestion, 4-site simplified scan, abnormal value >= 2), and coronary flow velocity reserve in left anterior descending artery (CFVR, abnormal value < 2.0). Local air quality indicators (same day of SE) of fine particulate matter (PM2.5) and nitrogen dioxide (NO2) were obtained from publicly available data sets of the regional authority of environmental protection. After lockdown, NO2 concentration decreased from 19 +/- 10 to 10 +/- 4 mu g/m(3) (p = 0.006). After lockdown, abnormal responses remained unchanged for ischemia (21% vs 16%, p = ns) and decreased for B-lines (42% vs 5%, p = 0.008) and CFVR (84 vs 42%, p = 0.007). Changes in coronary flow velocity reserve (CFVR) were correlated to same-day variations in NO2 (r = -0.578, p = 0.010) and preceding 30-day changes in PM2.5 (r = -0.518, p = 0.023). After lockdown, air cleaning was associated with a beneficial effect on coronary small vessel dysfunction and alveolar-capillary barrier distress mirrored by improvement of CFVR and B-lines during SE in vulnerable patients. 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