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[Further, oral administration of silymarin (500?mg/kg body weight/2� a week) significantly inhibited (60%, P?<?0.01) the growth of BRAF-mutated A375 melanoma tumor xenografts, and this was associated with: (i) inhibition of cell proliferation; (ii) induction of apoptosis of tumor cells; (iii) alterations in cell cycle regulatory proteins; and (iv) reduced expression of tumor angiogenic biomarkers in tumor xenograft tissues.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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