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[Effects of interferon-? on mRNA levels of all known human TLRs (TLR1-10) and the TLR adaptor molecule MyD88 were analyzed in peripheral blood mononuclear cells (PBMCs) of healthy donors by quantitative real-time PCR and by transcriptome analysis in PBMCs of 25 interferon-?-treated patients with relapsing-remitting MS. Regulation of TLR protein expression by interferon-? was investigated by flow cytometry of leukocyte subsets of healthy subjects and of untreated, interferon-?-, or glatiramer acetate-treated patients with MS. Interferon-? specifically upregulated mRNA expression of TLR3, TLR7, and MyD88 and downregulated TLR9 mRNA in PBMCs of healthy donors as well as in PBMCs of patients with MS. Plasmacytoid dendritic cells (pDCs) were identified as the major cell type responding to interferon-? with increased expression of TLR7 and MyD88 protein.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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