http://www.tkuhn.ch/bel2nanopub/RAPvvm7CnPX3ZAX737uVlNccWkGm1yZ8ciSp0k1AQtwNU#Head http://www.tkuhn.ch/bel2nanopub/RAPvvm7CnPX3ZAX737uVlNccWkGm1yZ8ciSp0k1AQtwNU http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAPvvm7CnPX3ZAX737uVlNccWkGm1yZ8ciSp0k1AQtwNU#assertion http://www.tkuhn.ch/bel2nanopub/RAPvvm7CnPX3ZAX737uVlNccWkGm1yZ8ciSp0k1AQtwNU http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAPvvm7CnPX3ZAX737uVlNccWkGm1yZ8ciSp0k1AQtwNU#provenance http://www.tkuhn.ch/bel2nanopub/RAPvvm7CnPX3ZAX737uVlNccWkGm1yZ8ciSp0k1AQtwNU http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAPvvm7CnPX3ZAX737uVlNccWkGm1yZ8ciSp0k1AQtwNU#pubinfo http://www.tkuhn.ch/bel2nanopub/RAPvvm7CnPX3ZAX737uVlNccWkGm1yZ8ciSp0k1AQtwNU http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAPvvm7CnPX3ZAX737uVlNccWkGm1yZ8ciSp0k1AQtwNU#assertion http://resource.belframework.org/belframework/20131211/namespace/selventa-named-complexes/p85%2Fp110%20PI3Kinase%20Complex http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0043234 http://www.tkuhn.ch/bel2nanopub/RAPvvm7CnPX3ZAX737uVlNccWkGm1yZ8ciSp0k1AQtwNU#_1 http://semanticscience.org/resource/SIO_000139 http://www.tkuhn.ch/bel2nanopub/RAPvvm7CnPX3ZAX737uVlNccWkGm1yZ8ciSp0k1AQtwNU#_2 http://www.tkuhn.ch/bel2nanopub/RAPvvm7CnPX3ZAX737uVlNccWkGm1yZ8ciSp0k1AQtwNU#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0016301 http://www.tkuhn.ch/bel2nanopub/RAPvvm7CnPX3ZAX737uVlNccWkGm1yZ8ciSp0k1AQtwNU#_2 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=3236 http://www.tkuhn.ch/bel2nanopub/RAPvvm7CnPX3ZAX737uVlNccWkGm1yZ8ciSp0k1AQtwNU#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAPvvm7CnPX3ZAX737uVlNccWkGm1yZ8ciSp0k1AQtwNU#_3 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=6018 http://www.tkuhn.ch/bel2nanopub/RAPvvm7CnPX3ZAX737uVlNccWkGm1yZ8ciSp0k1AQtwNU#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAPvvm7CnPX3ZAX737uVlNccWkGm1yZ8ciSp0k1AQtwNU#_4 http://semanticscience.org/resource/SIO_000139 http://resource.belframework.org/belframework/20131211/namespace/selventa-named-complexes/p85%2Fp110%20PI3Kinase%20Complex http://www.tkuhn.ch/bel2nanopub/RAPvvm7CnPX3ZAX737uVlNccWkGm1yZ8ciSp0k1AQtwNU#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0016301 http://www.tkuhn.ch/bel2nanopub/RAPvvm7CnPX3ZAX737uVlNccWkGm1yZ8ciSp0k1AQtwNU#_5 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAPvvm7CnPX3ZAX737uVlNccWkGm1yZ8ciSp0k1AQtwNU#_4 http://www.tkuhn.ch/bel2nanopub/RAPvvm7CnPX3ZAX737uVlNccWkGm1yZ8ciSp0k1AQtwNU#_5 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RAPvvm7CnPX3ZAX737uVlNccWkGm1yZ8ciSp0k1AQtwNU#_5 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RAPvvm7CnPX3ZAX737uVlNccWkGm1yZ8ciSp0k1AQtwNU#_3 http://www.tkuhn.ch/bel2nanopub/RAPvvm7CnPX3ZAX737uVlNccWkGm1yZ8ciSp0k1AQtwNU#_5 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAPvvm7CnPX3ZAX737uVlNccWkGm1yZ8ciSp0k1AQtwNU#_6 http://purl.obolibrary.org/obo/BFO_0000066 http://purl.obolibrary.org/obo/CLO_0009251 http://www.tkuhn.ch/bel2nanopub/RAPvvm7CnPX3ZAX737uVlNccWkGm1yZ8ciSp0k1AQtwNU#_6 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RAPvvm7CnPX3ZAX737uVlNccWkGm1yZ8ciSp0k1AQtwNU#_6 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAPvvm7CnPX3ZAX737uVlNccWkGm1yZ8ciSp0k1AQtwNU#_5 http://www.tkuhn.ch/bel2nanopub/RAPvvm7CnPX3ZAX737uVlNccWkGm1yZ8ciSp0k1AQtwNU#_6 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RAPvvm7CnPX3ZAX737uVlNccWkGm1yZ8ciSp0k1AQtwNU#_6 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RAPvvm7CnPX3ZAX737uVlNccWkGm1yZ8ciSp0k1AQtwNU#_1 http://www.tkuhn.ch/bel2nanopub/RAPvvm7CnPX3ZAX737uVlNccWkGm1yZ8ciSp0k1AQtwNU#_6 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAPvvm7CnPX3ZAX737uVlNccWkGm1yZ8ciSp0k1AQtwNU#assertion http://www.w3.org/2000/01/rdf-schema#label kin(p(HGNC:EGFR)) -> (p(HGNC:IL6) -> kin(complex(SCOMP:"p85/p110 PI3Kinase Complex"))) http://www.tkuhn.ch/bel2nanopub/RAPvvm7CnPX3ZAX737uVlNccWkGm1yZ8ciSp0k1AQtwNU#assertion http://www.w3.org/2000/01/rdf-schema#label p(HGNC:IL6) -> kin(complex(SCOMP:"p85/p110 PI3Kinase Complex")) http://www.tkuhn.ch/bel2nanopub/RAPvvm7CnPX3ZAX737uVlNccWkGm1yZ8ciSp0k1AQtwNU#provenance http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAPvvm7CnPX3ZAX737uVlNccWkGm1yZ8ciSp0k1AQtwNU#_8 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAPvvm7CnPX3ZAX737uVlNccWkGm1yZ8ciSp0k1AQtwNU#_7 http://www.w3.org/ns/prov#value Down-regulation of ErbB receptor activity, through the use of specific pharmacological inhibitors or dominant negative receptor constructs, revealed that IL-6-induced MAPK activation was largely dependent on epidermal growth factor (EGF) receptor activity, but not on ErbB-2 activity. Using a monoclonal antibody that interferes with EGF receptor-ligand interaction, we have shown that in T47D cells, IL-6 cooperates with an EGF receptor autocrine activity loop for signaling through the MAPK and PI3K pathways and for cell migration. http://www.tkuhn.ch/bel2nanopub/RAPvvm7CnPX3ZAX737uVlNccWkGm1yZ8ciSp0k1AQtwNU#_7 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11196191 http://www.tkuhn.ch/bel2nanopub/RAPvvm7CnPX3ZAX737uVlNccWkGm1yZ8ciSp0k1AQtwNU#_8 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAPvvm7CnPX3ZAX737uVlNccWkGm1yZ8ciSp0k1AQtwNU#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11196191 http://www.tkuhn.ch/bel2nanopub/RAPvvm7CnPX3ZAX737uVlNccWkGm1yZ8ciSp0k1AQtwNU#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAPvvm7CnPX3ZAX737uVlNccWkGm1yZ8ciSp0k1AQtwNU#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAPvvm7CnPX3ZAX737uVlNccWkGm1yZ8ciSp0k1AQtwNU#_7 http://www.tkuhn.ch/bel2nanopub/RAPvvm7CnPX3ZAX737uVlNccWkGm1yZ8ciSp0k1AQtwNU#pubinfo http://www.tkuhn.ch/bel2nanopub/RAPvvm7CnPX3ZAX737uVlNccWkGm1yZ8ciSp0k1AQtwNU http://purl.org/dc/terms/created 2014-07-03T14:31:39.812+02:00 http://www.tkuhn.ch/bel2nanopub/RAPvvm7CnPX3ZAX737uVlNccWkGm1yZ8ciSp0k1AQtwNU http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAPvvm7CnPX3ZAX737uVlNccWkGm1yZ8ciSp0k1AQtwNU http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234