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[Particularly, the sustained activation of epidermal growth factor receptor (EGFR), hedgehog, Wnt/?-catenin, Notch, hyaluronan (HA)/CD44 and stromal cell-derived factor-1 (SDF-1)/CXC chemokine receptor 4 (CXCR4) during the epithelial-mesenchymal transition (EMT) process may provide critical functions for PC progression to locally invasive, metastatic and androgen-independent disease states and treatment resistance.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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