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[Here we demonstrate for the first time that UPR is activated in s-IBM muscle biopsies, since there was 1) increased activating transcription factor 4 (ATF4) protein and increased mRNA of its target C/EBP homologous protein; 2) cleavage of the ATF6 and increased mRNA of its target glucose-regulated protein 78; and 3) an increase of the spliced form of X-box binding protein 1 and increased mRNA of ER degradation-enhancing ?-mannosidase-like protein, target of heterodimer of cleaved ATF6 and spliced X-box binding protein 1.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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