@prefix dct: <http://purl.org/dc/terms/> .
@prefix orcid: <http://orcid.org/> .
@prefix this: <http://rdf.disgenet.org/nanopublications.trig#NP43178.RAT4bCcOuxVAsZsq59BuHu2t7oYEB8lmoVTDDq7DVdcl8> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix sio: <http://semanticscience.org/resource/> .
@prefix ncit: <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#> .
@prefix lld: <http://linkedlifedata.com/resource/umls/id/> .
@prefix miriam-gene: <http://identifiers.org/ncbigene/> .
@prefix miriam-pubmed: <http://identifiers.org/pubmed/> .
@prefix eco: <http://purl.obolibrary.org/obo/eco.owl#> .
@prefix wi: <http://purl.org/ontology/wi/core#> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix pav: <http://purl.org/pav/2.0/> .
@prefix prv: <http://purl.org/net/provenance/ns#> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix dgn-np: <http://rdf.disgenet.org/nanopublications.trig#> .
@prefix dgn-gda: <http://rdf.disgenet.org/gene-disease-association.ttl#> .
@prefix dgn-void: <http://rdf.disgenet.org/v2.1.0/void.ttl#> .

dgn-np:NP43178.RAT4bCcOuxVAsZsq59BuHu2t7oYEB8lmoVTDDq7DVdcl8130_head {
  this: np:hasAssertion dgn-np:NP43178.RAT4bCcOuxVAsZsq59BuHu2t7oYEB8lmoVTDDq7DVdcl8130_assertion;
    np:hasProvenance dgn-np:NP43178.RAT4bCcOuxVAsZsq59BuHu2t7oYEB8lmoVTDDq7DVdcl8130_provenance;
    np:hasPublicationInfo dgn-np:NP43178.RAT4bCcOuxVAsZsq59BuHu2t7oYEB8lmoVTDDq7DVdcl8130_publicationInfo;
    a np:Nanopublication .
  
  dgn-np:NP43178.RAT4bCcOuxVAsZsq59BuHu2t7oYEB8lmoVTDDq7DVdcl8130_assertion a np:Assertion .
  
  dgn-np:NP43178.RAT4bCcOuxVAsZsq59BuHu2t7oYEB8lmoVTDDq7DVdcl8130_provenance a np:Provenance .
  
  dgn-np:NP43178.RAT4bCcOuxVAsZsq59BuHu2t7oYEB8lmoVTDDq7DVdcl8130_publicationInfo a
      np:PublicationInfo .
}

dgn-np:NP43178.RAT4bCcOuxVAsZsq59BuHu2t7oYEB8lmoVTDDq7DVdcl8130_assertion {
  miriam-gene:2944 a ncit:C16612 .
  
  lld:C0346647 a ncit:C7057 .
  
  dgn-gda:DGN3295ebefa83da08a34341c8f3c9501f4 sio:SIO_000628 miriam-gene:2944, lld:C0346647;
    a sio:SIO_001122 .
}

dgn-np:NP43178.RAT4bCcOuxVAsZsq59BuHu2t7oYEB8lmoVTDDq7DVdcl8130_provenance {
  dgn-np:NP43178.RAT4bCcOuxVAsZsq59BuHu2t7oYEB8lmoVTDDq7DVdcl8130_assertion dct:description
      "[No significant correlation was found between the level of 8-OH-dG and the MnSOD, GSTM1, and hOGG1 polymorphisms. However, one novel polymorphism/mutation of the hOGG1 gene was found in a pancreatic tumor. Mutation at codon 12 of the K-ras gene was found in 25 (81%) of 31 pancreatic tumors, including three G-to-A transitions and 22 G-to-T transversions. Patients with the G-to-T mutation had a significantly higher level of aromatic DNA adducts than those with G-to-A or wild-type codon (P=0.02). On the other hand, the K-ras mutation profile was not related to the level of 8-OH-dG. Given the limitation of sample size, these preliminary data lend further support the hypothesis that carcinogen exposure and oxidative stress are involved in pancreatic carcinogenesis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en;
    wi:evidence dgn-void:source_evidence_literature;
    sio:SIO_000772 miriam-pubmed:11719088;
    prov:wasDerivedFrom dgn-void:gad-20130706;
    prov:wasGeneratedBy eco:ECO_0000203 .
  
  dgn-void:gad-20130706 pav:importedOn "2013-07-06"^^xsd:date .
  
  dgn-void:source_evidence_literature a eco:ECO_0000212;
    rdfs:comment "Gene-disease associations inferred from text-mining the literature."@en;
    rdfs:label "DisGeNET evidence - LITERATURE"@en .
}

dgn-np:NP43178.RAT4bCcOuxVAsZsq59BuHu2t7oYEB8lmoVTDDq7DVdcl8130_publicationInfo {
  this: dct:created "2014-10-02T12:32:19+02:00"^^xsd:dateTime;
    dct:rights <http://opendatacommons.org/licenses/odbl/1.0/>;
    dct:rightsHolder dgn-void:IBIGroup;
    dct:subject sio:SIO_000983;
    prv:usedData dgn-void:disgenetrdf;
    pav:authoredBy orcid:0000-0001-5999-6269, orcid:0000-0002-7534-7661, orcid:0000-0002-9383-528X,
      orcid:0000-0003-0169-8159, orcid:0000-0003-1244-7654;
    pav:createdBy orcid:0000-0003-0169-8159;
    pav:version "v2.1.0.0" .
  
  dgn-void:disgenetrdf pav:version "v2.1.0" .
}