http://rdf.disgenet.org/resource/nanopub/NP852865.RATq1SyQlLISeuok3emFIhyLC2cZ4QLSq8I8TIpEM4xY0#head http://rdf.disgenet.org/resource/nanopub/NP852865.RATq1SyQlLISeuok3emFIhyLC2cZ4QLSq8I8TIpEM4xY0 http://www.nanopub.org/nschema#hasAssertion http://rdf.disgenet.org/resource/nanopub/NP852865.RATq1SyQlLISeuok3emFIhyLC2cZ4QLSq8I8TIpEM4xY0#assertion http://rdf.disgenet.org/resource/nanopub/NP852865.RATq1SyQlLISeuok3emFIhyLC2cZ4QLSq8I8TIpEM4xY0 http://www.nanopub.org/nschema#hasProvenance http://rdf.disgenet.org/resource/nanopub/NP852865.RATq1SyQlLISeuok3emFIhyLC2cZ4QLSq8I8TIpEM4xY0#provenance http://rdf.disgenet.org/resource/nanopub/NP852865.RATq1SyQlLISeuok3emFIhyLC2cZ4QLSq8I8TIpEM4xY0 http://www.nanopub.org/nschema#hasPublicationInfo http://rdf.disgenet.org/resource/nanopub/NP852865.RATq1SyQlLISeuok3emFIhyLC2cZ4QLSq8I8TIpEM4xY0#publicationInfo http://rdf.disgenet.org/resource/nanopub/NP852865.RATq1SyQlLISeuok3emFIhyLC2cZ4QLSq8I8TIpEM4xY0 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://rdf.disgenet.org/resource/nanopub/NP852865.RATq1SyQlLISeuok3emFIhyLC2cZ4QLSq8I8TIpEM4xY0#assertion http://rdf.disgenet.org/resource/gda/DGNc1e47445db4a5297613fc5ffe8016265 http://semanticscience.org/resource/SIO_000628 http://identifiers.org/ncbigene/5581 http://rdf.disgenet.org/resource/gda/DGNc1e47445db4a5297613fc5ffe8016265 http://semanticscience.org/resource/SIO_000628 http://linkedlifedata.com/resource/umls/id/C0151779 http://rdf.disgenet.org/resource/gda/DGNc1e47445db4a5297613fc5ffe8016265 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://semanticscience.org/resource/SIO_001123 http://rdf.disgenet.org/resource/nanopub/NP852865.RATq1SyQlLISeuok3emFIhyLC2cZ4QLSq8I8TIpEM4xY0#provenance http://rdf.disgenet.org/resource/nanopub/NP852865.RATq1SyQlLISeuok3emFIhyLC2cZ4QLSq8I8TIpEM4xY0#assertion http://purl.org/dc/terms/description [Now we present that (1) PKCvarepsilon physically interacts with Stat3alpha isoform in various human cancer cells: skin melanomas (MeWo and WM266-4), gliomas (T98G and MO59K), bladder (RT-4 and UM-UC-3), colon (Caco-2), lung (H1650), pancreatic (PANC-1), and breast (MCF-7 and MDA:MB-231); (2) inhibition of PKCvarepsilon expression using specific siRNA inhibits Stat3Ser727 phosphorylation, Stat3-DNA binding, Stat3-regulated gene expression as well as cell invasion; and (3) PKCvarepsilon mediates Stat3Ser727 phosphorylation through integration with the MAPK cascade (RAF-1, MEK1/2, and ERK1/2).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine. http://rdf.disgenet.org/resource/nanopub/NP852865.RATq1SyQlLISeuok3emFIhyLC2cZ4QLSq8I8TIpEM4xY0#assertion http://purl.org/ontology/wi/core#evidence http://rdf.disgenet.org/v5.0.0/void/source_evidence_literature http://rdf.disgenet.org/resource/nanopub/NP852865.RATq1SyQlLISeuok3emFIhyLC2cZ4QLSq8I8TIpEM4xY0#assertion http://semanticscience.org/resource/SIO_000772 http://identifiers.org/pubmed/20228845 http://rdf.disgenet.org/resource/nanopub/NP852865.RATq1SyQlLISeuok3emFIhyLC2cZ4QLSq8I8TIpEM4xY0#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://rdf.disgenet.org/v5.0.0/void/BEFREE http://rdf.disgenet.org/resource/nanopub/NP852865.RATq1SyQlLISeuok3emFIhyLC2cZ4QLSq8I8TIpEM4xY0#assertion http://www.w3.org/ns/prov#wasGeneratedBy http://purl.obolibrary.org/obo/ECO_0000203 http://rdf.disgenet.org/v5.0.0/void/BEFREE http://purl.org/pav/importedOn 2017-02-19 http://rdf.disgenet.org/v5.0.0/void/source_evidence_literature http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://purl.obolibrary.org/obo/ECO_0000212 http://rdf.disgenet.org/v5.0.0/void/source_evidence_literature http://www.w3.org/2000/01/rdf-schema#comment Gene-disease associations inferred from text-mining the literature. http://rdf.disgenet.org/v5.0.0/void/source_evidence_literature http://www.w3.org/2000/01/rdf-schema#label DisGeNET evidence - LITERATURE http://rdf.disgenet.org/resource/nanopub/NP852865.RATq1SyQlLISeuok3emFIhyLC2cZ4QLSq8I8TIpEM4xY0#publicationInfo http://rdf.disgenet.org/resource/nanopub/NP852865.RATq1SyQlLISeuok3emFIhyLC2cZ4QLSq8I8TIpEM4xY0 http://purl.org/dc/terms/created 2017-10-17T13:15:37+02:00 http://rdf.disgenet.org/resource/nanopub/NP852865.RATq1SyQlLISeuok3emFIhyLC2cZ4QLSq8I8TIpEM4xY0 http://purl.org/dc/terms/rights http://opendatacommons.org/licenses/odbl/1.0/ http://rdf.disgenet.org/resource/nanopub/NP852865.RATq1SyQlLISeuok3emFIhyLC2cZ4QLSq8I8TIpEM4xY0 http://purl.org/dc/terms/rightsHolder http://rdf.disgenet.org/v5.0.0/void/IBIGroup http://rdf.disgenet.org/resource/nanopub/NP852865.RATq1SyQlLISeuok3emFIhyLC2cZ4QLSq8I8TIpEM4xY0 http://purl.org/dc/terms/subject http://semanticscience.org/resource/SIO_000983 http://rdf.disgenet.org/resource/nanopub/NP852865.RATq1SyQlLISeuok3emFIhyLC2cZ4QLSq8I8TIpEM4xY0 http://purl.org/net/provenance/ns#usedData http://rdf.disgenet.org/v5.0.0/void/disgenetv3.0rdf http://rdf.disgenet.org/resource/nanopub/NP852865.RATq1SyQlLISeuok3emFIhyLC2cZ4QLSq8I8TIpEM4xY0 http://purl.org/pav/authoredBy http://orcid.org/0000-0001-5999-6269 http://rdf.disgenet.org/resource/nanopub/NP852865.RATq1SyQlLISeuok3emFIhyLC2cZ4QLSq8I8TIpEM4xY0 http://purl.org/pav/authoredBy http://orcid.org/0000-0002-7534-7661 http://rdf.disgenet.org/resource/nanopub/NP852865.RATq1SyQlLISeuok3emFIhyLC2cZ4QLSq8I8TIpEM4xY0 http://purl.org/pav/authoredBy http://orcid.org/0000-0002-9383-528X http://rdf.disgenet.org/resource/nanopub/NP852865.RATq1SyQlLISeuok3emFIhyLC2cZ4QLSq8I8TIpEM4xY0 http://purl.org/pav/authoredBy http://orcid.org/0000-0003-0169-8159 http://rdf.disgenet.org/resource/nanopub/NP852865.RATq1SyQlLISeuok3emFIhyLC2cZ4QLSq8I8TIpEM4xY0 http://purl.org/pav/authoredBy http://orcid.org/0000-0003-1244-7654 http://rdf.disgenet.org/resource/nanopub/NP852865.RATq1SyQlLISeuok3emFIhyLC2cZ4QLSq8I8TIpEM4xY0 http://purl.org/pav/createdBy http://orcid.org/0000-0003-0169-8159 http://rdf.disgenet.org/resource/nanopub/NP852865.RATq1SyQlLISeuok3emFIhyLC2cZ4QLSq8I8TIpEM4xY0 http://purl.org/pav/version v5.0.0.0 http://rdf.disgenet.org/v5.0.0/void/disgenetv3.0rdf http://purl.org/pav/version v5.0.0