@prefix nt: <https://w3id.org/np/o/ntemplate/> .
@prefix this: <http://purl.org/np/RAY8Y7aCkiEfQgD3nCfROJiyZlqGXZEPKqXFkUiZ1MyR8> .
@prefix sub: <http://purl.org/np/RAY8Y7aCkiEfQgD3nCfROJiyZlqGXZEPKqXFkUiZ1MyR8#> .
@prefix drugbank: <http://identifiers.org/drugbank/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix mondo: <http://purl.obolibrary.org/obo/MONDO_> .
@prefix pav: <http://purl.org/pav/> .
@prefix infores: <https://w3id.org/biolink/infores/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix orcid: <https://orcid.org/> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix pmid: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix ncit: <http://purl.obolibrary.org/obo/NCIT_> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix biolink: <https://w3id.org/biolink/vocab/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix npx: <http://purl.org/nanopub/x/> .
sub:Head {
   this: np:hasAssertion sub:assertion ;
    np:hasProvenance sub:provenance ;
    np:hasPublicationInfo sub:pubInfo ;
    a np:Nanopublication .
}
sub:assertion {
   drugbank:DB00657 a biolink:Drug ;
    rdfs:label "Mecamylamine" ;
    biolink:category biolink:Drug .
  mondo:0007079 a biolink:Disease ;
    rdfs:label "alcohol depedence" ;
    biolink:category biolink:Disease .
  sub:association rdf:object mondo:0007079 ;
    rdf:predicate biolink:treats ;
    rdf:subject drugbank:DB00657 ;
    a biolink:ChemicalToDiseaseOrPhenotypicFeatureAssociation ;
    rdfs:label "The nicotinic-acetylcholine receptor (nAchR)- antagonist mecamylanine has been found to reduce the stimulus produced by ethanol in human lab studies. The nAchR-antagonist varenicline has also displayed positive effect in reducing alcohol consumption in multiple clinical trials. In this 12- week double-blind trial, participants (n 1⁄4 126) were randomized to either mecamylamine (10 mg daily) or placebo. No medication effect was found for reducing heavy drinking days (HDD) or alcohol craving. Smoking status had no effect on the results. The authors suggest that broad-spectrum nAchR-antagonists may not be beneficial in treat- ing AUD" ;
    biolink:aggregator_knowledge_source infores:knowledge-collaboratory ;
    biolink:category biolink:ChemicalToDiseaseOrPhenotypicFeatureAssociation ;
    biolink:has_population_context sub:context ;
    biolink:publications pmid:30973369 ;
    biolink:relation ncit:C94303 .
  sub:context a biolink:Cohort ;
    rdfs:label "Adults" ;
    biolink:category biolink:Cohort .
}
sub:provenance {
   sub:assertion prov:wasAttributedTo orcid:0000-0002-7641-6446 .
}
sub:pubInfo {
   sub:sig npx:hasAlgorithm "RSA" ;
    npx:hasPublicKey "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCR9fz0fKCdWOWC+pxhkQhEM/ppbdIYe5TLSdj+lJzSlv9mYBaPgrzVezSwwbmhlHBPDZa4/vHycU315BdmUGq+pXllp9+rWFfrb+kBJwhZjpG6BeyyXBsRFz4jmQVxl/ZYHilQTh/XalYzKkEAyTiEMPee4Kz61PaWOKH24CsnOQIDAQAB" ;
    npx:hasSignature "Fo8BBofLMb7gbbEd6GNEKc7Srrw7bp3abs8XZKatBi/ZcgMAfw+LyWgaBrD+AZGJxgqt4rNzLJqWUbgg8+UafYoOoIo2oGRJnNnDuNqY5bufOrO3RNgCAkdruY53LC7VU6GH1YpQe6/iXaviPqcvxOwMkY2fu9kZEDJO2571dCk=" ;
    npx:hasSignatureTarget this: .
  this: prov:generatedAtTime "2022-09-16T11:51:33.680448"^^xsd:dateTime ;
    prov:wasAttributedTo orcid:0000-0002-1501-1082 ;
    nt:wasCreatedFromTemplate <http://purl.org/np/RAhNHZw6Urw_Mccs4qy6Ws3C9CRuaHpQx8AwuApbWkqnY> .
  biolink: pav:version "2.3.0" .
}