@prefix this: <http://rdf.disgenet.org/nanopublications.trig#NP166932.RAbHI1KexARHMhOmTxMP8zFCv2B6RIQ1TbIxH8dtJulYE> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix sio: <http://semanticscience.org/resource/> .
@prefix ncit: <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#> .
@prefix lld: <http://linkedlifedata.com/resource/umls/id/> .
@prefix miriam-gene: <http://identifiers.org/ncbigene/> .
@prefix miriam-pubmed: <http://identifiers.org/pubmed/> .
@prefix eco: <http://purl.obolibrary.org/obo/eco.owl#> .
@prefix wi: <http://purl.org/ontology/wi/core#> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix pav: <http://purl.org/pav/2.0/> .
@prefix prv: <http://purl.org/net/provenance/ns#> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix dgn-np: <http://rdf.disgenet.org/nanopublications.trig#> .
@prefix dgn-gda: <http://rdf.disgenet.org/gene-disease-association.ttl#> .
@prefix dgn-void: <http://rdf.disgenet.org/v2.1.0/void.ttl#> .

dgn-np:NP166932.RAbHI1KexARHMhOmTxMP8zFCv2B6RIQ1TbIxH8dtJulYE130_head {
  this: np:hasAssertion dgn-np:NP166932.RAbHI1KexARHMhOmTxMP8zFCv2B6RIQ1TbIxH8dtJulYE130_assertion;
    np:hasProvenance dgn-np:NP166932.RAbHI1KexARHMhOmTxMP8zFCv2B6RIQ1TbIxH8dtJulYE130_provenance;
    np:hasPublicationInfo dgn-np:NP166932.RAbHI1KexARHMhOmTxMP8zFCv2B6RIQ1TbIxH8dtJulYE130_publicationInfo;
    a np:Nanopublication .
  
  dgn-np:NP166932.RAbHI1KexARHMhOmTxMP8zFCv2B6RIQ1TbIxH8dtJulYE130_assertion a np:Assertion .
  
  dgn-np:NP166932.RAbHI1KexARHMhOmTxMP8zFCv2B6RIQ1TbIxH8dtJulYE130_provenance a np:Provenance .
  
  dgn-np:NP166932.RAbHI1KexARHMhOmTxMP8zFCv2B6RIQ1TbIxH8dtJulYE130_publicationInfo a
      np:PublicationInfo .
}

dgn-np:NP166932.RAbHI1KexARHMhOmTxMP8zFCv2B6RIQ1TbIxH8dtJulYE130_assertion {
  miriam-gene:5371 a ncit:C16612 .
  
  lld:C0023524 a ncit:C7057 .
  
  dgn-gda:DGN37afa873d0fb654f36c8fef0b488b59d sio:SIO_000628 miriam-gene:5371, lld:C0023524;
    a sio:SIO_001121 .
}

dgn-np:NP166932.RAbHI1KexARHMhOmTxMP8zFCv2B6RIQ1TbIxH8dtJulYE130_provenance {
  dgn-np:NP166932.RAbHI1KexARHMhOmTxMP8zFCv2B6RIQ1TbIxH8dtJulYE130_assertion dcterms:description
      "[Here we report that (i) As2O3 induces apoptosis only in cells expressing the PML-RARalpha, not the PLZF-RARalpha, fusion protein; (ii) PML-RARalpha is partially modified by covalent linkage with a PIC-1/SUMO-1-like protein prior to As2O3 treatment, whereas PLZF-RARalpha is not; (iii) As2O3 treatment induces a change in the modification pattern of PML-RARalpha toward highly modified forms; (iv) redistribution of PML nuclear bodies (PML-NBs) upon As2O3 treatment is accompanied by recruitment of PIC-1/SUMO-1 into PML-NBs, probably due to hypermodification of both PML and PML-RARalpha; (v) As2O3-induced apoptosis is independent of the DNA binding activity located in the RARalpha portion of the PML-RARalpha fusion protein; and (vi) the apoptotic process is bcl-2 and caspase 3 independent and is blocked only partially by a global caspase inhibitor.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en;
    wi:evidence dgn-void:source_evidence_literature;
    sio:SIO_000772 miriam-pubmed:10373566;
    prov:wasDerivedFrom dgn-void:befree-20140225;
    prov:wasGeneratedBy eco:ECO_0000203 .
  
  dgn-void:befree-20140225 pav:importedOn "2014-02-25"^^xsd:date .
  
  dgn-void:source_evidence_literature a eco:ECO_0000212;
    rdfs:comment "Gene-disease associations inferred from text-mining the literature."@en;
    rdfs:label "DisGeNET evidence - LITERATURE"@en .
}

dgn-np:NP166932.RAbHI1KexARHMhOmTxMP8zFCv2B6RIQ1TbIxH8dtJulYE130_publicationInfo {
  this: dcterms:created "2014-10-02T12:33:30+02:00"^^xsd:dateTime;
    dcterms:rights <http://opendatacommons.org/licenses/odbl/1.0/>;
    dcterms:rightsHolder dgn-void:IBIGroup;
    dcterms:subject sio:SIO_000983;
    prv:usedData dgn-void:disgenetrdf;
    pav:authoredBy <http://orcid.org/0000-0001-5999-6269>, <http://orcid.org/0000-0002-7534-7661>,
      <http://orcid.org/0000-0002-9383-528X>, <http://orcid.org/0000-0003-0169-8159>, <http://orcid.org/0000-0003-1244-7654>;
    pav:createdBy <http://orcid.org/0000-0003-0169-8159>;
    pav:version "v2.1.0.0" .
  
  dgn-void:disgenetrdf pav:version "v2.1.0" .
}