@prefix dc1: <
http://purl.org/dc/terms/
> .
@prefix this: <
http://purl.org/np/RAbkpODkf020xyvZdFpUNPeUnSlMy6dZblJDo9kjepfOY
> .
@prefix sub: <
http://purl.org/np/RAbkpODkf020xyvZdFpUNPeUnSlMy6dZblJDo9kjepfOY#
> .
@prefix schema: <
https://schema.org/
> .
@prefix np: <
http://www.nanopub.org/nschema#
> .
@prefix rdf: <
http://www.w3.org/1999/02/22-rdf-syntax-ns#
> .
@prefix nt: <
https://w3id.org/np/o/ntemplate/
> .
@prefix xsd: <
http://www.w3.org/2001/XMLSchema#
> .
@prefix rdfs: <
http://www.w3.org/2000/01/rdf-schema#
> .
@prefix orcid: <
https://orcid.org/
> .
@prefix bl: <
https://w3id.org/biolink/vocab/
> .
@prefix prov: <
http://www.w3.org/ns/prov#
> .
@prefix npx: <
http://purl.org/nanopub/x/
> .
sub:Head
{
this:
np:hasAssertion
sub:assertion
;
np:hasProvenance
sub:provenance
;
np:hasPublicationInfo
sub:pubinfo
;
a
np:Nanopublication
.
}
sub:assertion
{
<
http://purl.obolibrary.org/obo/DOID_9253
>
bl:category
bl:Disease
.
sub:association
rdf:object
<
http://purl.obolibrary.org/obo/DOID_9253
> ;
rdf:predicate
bl:treats
;
rdf:subject
<
https://identifiers.org/drugbank:DB08896
> ;
a
rdf:Statement
;
rdfs:label
"stivarga is a kinase inhibitor indicated for the treatment of patients with 1 1 1 2 stivarga is indicated for the treatment of patients with metastatic colorectal cancer crc who have been previously treated with fluoropyrimidine oxaliplatin and irinotecan based chemotherapy an anti vegf therapy and if ras wild type an anti egfr therapy stivarga is indicated for the treatment of patients with locally advanced unresectable or metastatic gastrointestinal stromal tumor gist who have been previously treated with imatinib mesylate and sunitinib malate stivarga is indicated for the treatment of patients with hepatocellular carcinoma hcc who have been previously treated with sorafenib" ;
bl:association_type
bl:ChemicalToDiseaseOrPhenotypicFeatureAssociation
;
bl:provided_by
<
https://w3id.org/um/NeuroDKG
> ;
bl:relation
schema:TreatmentIndication
.
<
https://identifiers.org/drugbank:DB08896
>
bl:category
bl:Drug
.
}
sub:provenance
{
sub:assertion
prov:wasAttributedTo
orcid:0000-0002-1468-3557
.
}
sub:pubinfo
{
sub:sig
npx:hasAlgorithm
"RSA" ;
npx:hasPublicKey
"MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCODwZkXojpEKwk7Ldj2oPPfCstvqrcpgCaTLo235K7ht9C7E1GCkLvUuL2b4VWXJTcZx/hxgDauR8hUeYq/lS6tfTL9yFZsnfl+PWYDyz7vv6N+wJVx2LL8bO6ntCjcOzvW2t2WUeF12Sb6b3I6uOYP0N8iQKts1WasY/yEYKAHQIDAQAB" ;
npx:hasSignature
"e8IYKCAPFzSbZkByn9TqSSmsX3mC+eLS1JbPT5wchH9wl6AnqmFlOpbUoicMm1uo4RHbfy9eqVCEuC9VPANAsLlOWE83UsdtTOWuoGeE+/jw4CTuDxkq12p/I7k8havuMWI4QEmE9UBp+811LTFTHZ0tIjFl8U2DSJk9uK2BOWA=" ;
npx:hasSignatureTarget
this:
.
this:
dc1:created
"2021-06-12T14:55:59.525+02:00"^^
xsd:dateTime
;
dc1:creator
orcid:0000-0002-1468-3557
;
nt:wasCreatedFromProvenanceTemplate
<
http://purl.org/np/RANwQa4ICWS5SOjw7gp99nBpXBasapwtZF1fIM3H2gYTM
> ;
nt:wasCreatedFromPubinfoTemplate
<
http://purl.org/np/RAA2MfqdBCzmz9yVWjKLXNbyfBNcwsMmOqcNUxkk1maIM
> ;
nt:wasCreatedFromTemplate
<
http://purl.org/np/RAManV5GZI01JKzW_IPcfOXoiFTcZMmsV7qTCLkdzr4Gs
> .
}