sub:assertion {
  <http://purl.obolibrary.org/obo/DOID_10763> bl:category bl:Disease .
  sub:association rdf:object <http://purl.obolibrary.org/obo/DOID_10763> ;
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    rdf:subject <https://identifiers.org/drugbank:DB00264> ;
    a rdf:Statement ;
    rdfs:label "metoprolol succinate extended release tablets metoprolol succinate is a beta selective adrenoceptor blocking agent 1 metoprolol succinate extended release tablets are indicated for the treatment of hypertension to lower blood pressure lowering blood pressure reduces the risk of fatal and non fatal cardiovascular events primarily strokes and myocardial infarctions 1 1 1 angina pectoris 2 1 2 heart failure for the treatment of stable symptomatic nyha class ii or iii heart failure of ischemic hypertensive or cardiomyopathic origin 3 1 3 metoprolol succinate extended release tablets are indicated for the treatment of hypertension to lower blood pressure lowering blood pressure lowers the risk of fatal and non fatal cardiovascular events primarily strokes and myocardial infarctions these benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes including metoprolol control of high blood pressure should be part of comprehensive cardiovascular risk management including as appropriate lipid control diabetes management antithrombotic therapy smoking cessation exercise and limited sodium intake many patients will require more than 1 drug to achieve blood pressure goals for specific advice on goals and management see published guidelines such as those of the national high blood pressure education program s joint national committee on prevention detection evaluation and treatment of high blood pressure jnc numerous antihypertensive drugs from a variety of pharmacologic classes and with different mechanisms of action have been shown in randomized controlled trials to reduce cardiovascular morbidity and mortality and it can be concluded that it is blood pressure reduction and not some other pharmacologic property of the drugs that is largely responsible for those benefits the largest and most consistent cardiovascular outcome benefit has been a reduction in the risk of stroke but reductions in myocardial infarction and cardiovascular mortality also have been seen regularly elevated systolic or diastolic pressure causes increased cardiovascular risk and the absolute risk increase per mmhg is greater at higher blood pressures so that even modest reductions of severe hypertension can provide substantial benefit relative risk reduction from blood pressure reduction is similar across populations with varying absolute risk so the absolute benefit is greater in patients who are at higher risk independent of their hypertension for example patients with diabetes or hyperlipidemia and such patients would be expected to benefit from more aggressive treatment to a lower blood pressure goal some antihypertensive drugs have smaller blood pressure effects as monotherapy in black patients and many antihypertensive drugs have additional approved indications and effects eg on angina heart failure or diabetic kidney disease these considerations may guide selection of therapy metoprolol succinate extended release tablets may be administered with other antihypertensive agents metoprolol succinate extended release tablets are indicated in the long term treatment of angina pectoris to reduce angina attacks and to improve exercise tolerance metoprolol succinate extended release tablets are indicated for the treatment of stable symptomatic nyha class ii or iii heart failure of ischemic hypertensive or cardiomyopathic origin it was studied in patients already receiving ace inhibitors diuretics and in the majority of cases digitalis in this population metoprolol succinate extended release tablets decreased the rate of mortality plus hospitalization largely through a reduction in cardiovascular mortality and hospitalizations for heart failure" ;
    bl:association_type bl:ChemicalToDiseaseOrPhenotypicFeatureAssociation ;
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    bl:relation schema:TreatmentIndication .
  <https://identifiers.org/drugbank:DB00264> bl:category bl:Drug .
}