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[Contrary to the current AD model which positions BACE1 (?-secretase) as an aberrant or AD-advancing enzyme, it is proposed herein that the neuron's protective counteraction to this metal toxicity is, in fact, a justified increase in BACE1 activity and amyloid precursor protein (APP) processing to yield more secreted APP (sAPP) and ?-amyloid peptide in response to metal toxicity.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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