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[Here, we analyzed the impact of the different HLA-DR15 haplotype alleles on disease susceptibility in a new 'humanized' model of MS induced in HLA-transgenic (Tg) mice by human oligodendrocyte-specific protein (OSP)/claudin-11 (hOSP), one of the bona fide potential primary target antigens in MS. We show that the hOSP-associated MS-like disease is dominated by the DRB1*15:01 allele not only as the DRA1*01:01;DRB1*15:01 isotypic heterodimer but also, unexpectedly, as a functional DQA1*01:02;DRB1*15:01 mixed isotype heterodimer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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