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@prefix sub: <http://purl.org/np/RAflwB6PeyN7guVfAiONQl7MjSU7VoNwYOoKSFzFbdCeM#> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix pav: <http://purl.org/pav/> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix infores: <https://w3id.org/biolink/infores/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix umls: <http://identifiers.org/umls/> .
@prefix orcid: <https://orcid.org/> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix biolink: <https://w3id.org/biolink/vocab/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix npx: <http://purl.org/nanopub/x/> .
sub:Head {
   this: np:hasAssertion sub:assertion ;
    np:hasProvenance sub:provenance ;
    np:hasPublicationInfo sub:pubInfo ;
    a np:Nanopublication .
}
sub:assertion {
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    rdfs:label "familial hypercholesterolemia" ;
    biolink:category biolink:DiseaseOrPhenotypicFeature .
  umls:C0020476 a biolink:DiseaseOrPhenotypicFeature ;
    rdfs:label "hyperlipidemia" ;
    biolink:category biolink:DiseaseOrPhenotypicFeature .
  umls:C1416822 a biolink:ChemicalEntity ;
    rdfs:label "LDL-C." ;
    biolink:category biolink:ChemicalEntity .
  <http://purl.obolibrary.org/obo/MONDO_0004995> a biolink:DiseaseOrPhenotypicFeature ;
    rdfs:label "cardiovascular disease" ;
    biolink:category biolink:DiseaseOrPhenotypicFeature .
  <http://purl.obolibrary.org/obo/MONDO_0005068> a biolink:DiseaseOrPhenotypicFeature ;
    rdfs:label "myocardial infarction" ;
    biolink:category biolink:DiseaseOrPhenotypicFeature .
  <http://purl.obolibrary.org/obo/MONDO_0005098> a biolink:DiseaseOrPhenotypicFeature ;
    rdfs:label "stroke" ;
    biolink:category biolink:DiseaseOrPhenotypicFeature .
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    rdf:predicate biolink:treats ;
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    a biolink:Association ;
    biolink:aggregator_knowledge_source infores:knowledge-collaboratory ;
    biolink:category biolink:Association ;
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  sub:_10 rdf:object <file:///app/HeFH> ;
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    a biolink:Association ;
    biolink:aggregator_knowledge_source infores:knowledge-collaboratory ;
    biolink:category biolink:Association ;
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    biolink:aggregator_knowledge_source infores:knowledge-collaboratory ;
    biolink:category biolink:Association ;
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  sub:_15 rdf:object <http://identifiers.org/ncbigene/3949> ;
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    biolink:category biolink:Association ;
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  sub:_18 rdf:object umls:C1416822 ;
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    a biolink:Association ;
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    biolink:category biolink:Association ;
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  sub:_23 rdf:object <file:///app/LDL-C)-lowering> ;
    rdf:predicate biolink:treats ;
    rdf:subject <file:///app/REPATHA> ;
    a biolink:Association ;
    biolink:aggregator_knowledge_source infores:knowledge-collaboratory ;
    biolink:category biolink:Association ;
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    rdf:predicate biolink:associated_with ;
    rdf:subject <http://purl.obolibrary.org/obo/MONDO_0004995> ;
    a biolink:Association ;
    biolink:aggregator_knowledge_source infores:knowledge-collaboratory ;
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    rdf:subject <file:///app/REPATHA> ;
    a biolink:Association ;
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  sub:_5 rdf:object <file:///app/HeFH> ;
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    rdf:subject umls:C1416822 ;
    a biolink:Association ;
    biolink:aggregator_knowledge_source infores:knowledge-collaboratory ;
    biolink:category biolink:Association ;
    biolink:publications <https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1967dc24-f2a5-4095-baa9-a9d1c5410311> .
  sub:_6 rdf:object <file:///app/HeFH> ;
    rdf:predicate biolink:treats ;
    rdf:subject <file:///app/LDL-C)-lowering> ;
    a biolink:Association ;
    biolink:aggregator_knowledge_source infores:knowledge-collaboratory ;
    biolink:category biolink:Association ;
    biolink:publications <https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1967dc24-f2a5-4095-baa9-a9d1c5410311> .
  sub:_7 rdf:object <http://identifiers.org/ncbigene/3949> ;
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    a biolink:Association ;
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    biolink:publications <https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1967dc24-f2a5-4095-baa9-a9d1c5410311> .
  sub:_8 rdf:object umls:C0020476 ;
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    a biolink:Association ;
    biolink:aggregator_knowledge_source infores:knowledge-collaboratory ;
    biolink:category biolink:Association ;
    biolink:publications <https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1967dc24-f2a5-4095-baa9-a9d1c5410311> .
  sub:_9 rdf:object <file:///app/LDL-C)-lowering> ;
    rdf:predicate biolink:associated_with ;
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}
sub:provenance {
   sub:assertion prov:generatedAtTime "2022-10-10T14:39:40.187124"^^xsd:dateTime ;
    prov:wasAttributedTo orcid:0000-0002-3668-2627 ;
    prov:wasQuotedFrom " REPATHA is indicated in adults with established cardiovascular disease to reduce the risk of myocardial infarction, stroke, and coronary revascularization. It is an adjunct to diet, alone or in combination with other low-density lipoprotein cholesterol (LDL-C)-lowering therapies, to reduce LDL-C. In adults with primary hyperlipidemia, including heterozygous familial hypercholesterolemia (HeFH)" .
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