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[About 70% of PHP-Ia patients, who show Albright hereditary osteodystrophy (AHO) associated with resistance toward multiple hormones (PTH/TSH/GHRH/gonadotropins), carry heterozygous mutations in the ?-subunit of the stimulatory G protein (Gs?) exons 1-13, encoded by the guanine nucleotide binding-protein ?-stimulating activity polypeptide 1 (GNAS), whereas the majority of PHP-Ib patients, who classically display hormone resistance limited to PTH and TSH with no AHO sign, have methylation defects in the imprinted GNAS cluster.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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