@prefix biolink: <https://w3id.org/biolink/vocab/> .
@prefix ns1: <https://w3id.org/np/o/ntemplate/> .
@prefix this: <http://purl.org/np/RAgh2GWrIocWT5uQ4s-hBjUoGJH3QZLXfN1C4-u2qsJOo> .
@prefix sub: <http://purl.org/np/RAgh2GWrIocWT5uQ4s-hBjUoGJH3QZLXfN1C4-u2qsJOo#> .
@prefix schema: <https://schema.org/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix orcid: <https://orcid.org/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix npx: <http://purl.org/nanopub/x/> .
sub:Head {
   this: np:hasAssertion sub:assertion ;
    np:hasProvenance sub:provenance ;
    np:hasPublicationInfo sub:pubinfo ;
    a np:Nanopublication .
}
sub:assertion {
   <http://purl.obolibrary.org/obo/DOID_2841> biolink:category biolink:Disease .
  sub:association rdf:object <http://purl.obolibrary.org/obo/DOID_2841> ;
    rdf:predicate biolink:treats ;
    rdf:subject <https://identifiers.org/drugbank:DB00813> ;
    a rdf:Statement ;
    rdfs:label "\"IONSYS is contraindicated in patients with:   Significant respiratory depression   [see Warnings and Precautions (  5.1   Acute or severe bronchial asthma in an unmonitored setting or in the absence of resuscitative equipment  [see Warnings and Precautions (  5.1 Known or suspected gastrointestinal obstruction, including paralytic ileus  [see Warnings and Precautions (  5.13 Hypersensitivity to fentanyl, cetylpyridinium chloride (e.g., Cepacol(r)), or any components of IONSYS  [see Adverse Reactions (  6.1 6.2   Significant respiratory depression. (  4 Acute or severe bronchial asthma in an unmonitored setting or in absence of resuscitative equipment. (  4 Known or suspected gastrointestinal obstruction, including paralytic ileus. (  4 Hypersensitivity to fentanyl, cetylpyridinium chloride (e.g., Cepacol  (r) 4\"" ;
    biolink:provided_by <https://w3id.org/um/NeuroDKG> ;
    biolink:relation schema:MedicalContraindication .
  <https://identifiers.org/drugbank:DB00813> biolink:category biolink:Drug .
}
sub:provenance {
   sub:assertion prov:wasAttributedTo orcid:0000-0002-1468-3557 .
}
sub:pubinfo {
   sub:sig npx:hasAlgorithm "RSA" ;
    npx:hasPublicKey "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCODwZkXojpEKwk7Ldj2oPPfCstvqrcpgCaTLo235K7ht9C7E1GCkLvUuL2b4VWXJTcZx/hxgDauR8hUeYq/lS6tfTL9yFZsnfl+PWYDyz7vv6N+wJVx2LL8bO6ntCjcOzvW2t2WUeF12Sb6b3I6uOYP0N8iQKts1WasY/yEYKAHQIDAQAB" ;
    npx:hasSignature "e1kp2zmixUy2PY9Z8MU9MxzvD3BU0kEM62/2vv6BrONF+5tc3Wrtjsqrn/9i+tzS20XMshZppHDUGkypr6BpogIv0HQi9B+URPSbHh+3iYW5iKUMbTjGqtE1z88Ku1ACtrgiTUnfcAx1pgLgJtbiMaJbyXf09Hodo/ccQLChtL8=" ;
    npx:hasSignatureTarget this: .
  this: dct:created "2021-08-23T12:53:47.152+02:00"^^xsd:dateTime ;
    dct:creator orcid:0000-0002-1468-3557 ;
    ns1:wasCreatedFromProvenanceTemplate <http://purl.org/np/RANwQa4ICWS5SOjw7gp99nBpXBasapwtZF1fIM3H2gYTM> ;
    ns1:wasCreatedFromPubinfoTemplate <http://purl.org/np/RAA2MfqdBCzmz9yVWjKLXNbyfBNcwsMmOqcNUxkk1maIM> ;
    ns1:wasCreatedFromTemplate <http://purl.org/np/RAhNHZw6Urw_Mccs4qy6Ws3C9CRuaHpQx8AwuApbWkqnY> .
}