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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAiIGFZadN72SRLRGTdJRB6IIbLDFxX5x9LYmfIJJKMtY#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAiIGFZadN72SRLRGTdJRB6IIbLDFxX5x9LYmfIJJKMtY#_4 http://www.w3.org/ns/prov#value To determine the functional importance of this AP-1 site, we used site-directed mutagenesis to generate a 1.4 kb CD44 5'-promoter construct containing an AP-1 site mutation, CD44(-1,262/+109AP-1m). A comparable mutation of the AP-1 motif in the human CD44 promoter (TTAGTCA to CTAGGCA) disrupts the function of this site (53) . In comparison with the native CD44(-1,262/+109) construct, the CD44(-1,262/+109AP-1m) construct displayed a 51% reduction in promoter activity in RASMC after stimulation by IL-1ß http://www.tkuhn.ch/bel2nanopub/RAiIGFZadN72SRLRGTdJRB6IIbLDFxX5x9LYmfIJJKMtY#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/10657993 http://www.tkuhn.ch/bel2nanopub/RAiIGFZadN72SRLRGTdJRB6IIbLDFxX5x9LYmfIJJKMtY#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAiIGFZadN72SRLRGTdJRB6IIbLDFxX5x9LYmfIJJKMtY#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/10657993 http://www.tkuhn.ch/bel2nanopub/RAiIGFZadN72SRLRGTdJRB6IIbLDFxX5x9LYmfIJJKMtY#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAiIGFZadN72SRLRGTdJRB6IIbLDFxX5x9LYmfIJJKMtY#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAiIGFZadN72SRLRGTdJRB6IIbLDFxX5x9LYmfIJJKMtY#_4 http://www.tkuhn.ch/bel2nanopub/RAiIGFZadN72SRLRGTdJRB6IIbLDFxX5x9LYmfIJJKMtY#pubinfo http://www.tkuhn.ch/bel2nanopub/RAiIGFZadN72SRLRGTdJRB6IIbLDFxX5x9LYmfIJJKMtY http://purl.org/dc/terms/created 2014-07-03T14:29:49.908+02:00 http://www.tkuhn.ch/bel2nanopub/RAiIGFZadN72SRLRGTdJRB6IIbLDFxX5x9LYmfIJJKMtY http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAiIGFZadN72SRLRGTdJRB6IIbLDFxX5x9LYmfIJJKMtY http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234