@prefix dc1: <http://purl.org/dc/terms/> .
@prefix this: <http://purl.org/np/RAiN44emSZ4jKhIYxOdE0op-3bvqTZF2OASOELEQhBPr0> .
@prefix sub: <http://purl.org/np/RAiN44emSZ4jKhIYxOdE0op-3bvqTZF2OASOELEQhBPr0#> .
@prefix schema: <https://schema.org/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix nt: <https://w3id.org/np/o/ntemplate/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix orcid: <https://orcid.org/> .
@prefix bl: <https://w3id.org/biolink/vocab/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix npx: <http://purl.org/nanopub/x/> .
sub:Head {
   this: np:hasAssertion sub:assertion ;
    np:hasProvenance sub:provenance ;
    np:hasPublicationInfo sub:pubinfo ;
    a np:Nanopublication .
}
sub:assertion {
   <http://purl.obolibrary.org/obo/DOID_7148> bl:category bl:Disease .
  sub:association rdf:object <http://purl.obolibrary.org/obo/DOID_7148> ;
    rdf:predicate bl:treats ;
    rdf:subject <https://identifiers.org/drugbank:DB01281> ;
    a rdf:Statement ;
    rdfs:label "orencia is a selective t cell costimulation modulator indicated for adult rheumatoid arthritis ra 1 1 1 1 juvenile idiopathic arthritis 1 2 1 2 adult psoriatic arthritis psa 1 3 1 3 important limitations of use 1 4 1 4 5 1 orencia r orencia is indicated for reducing signs and symptoms in patients 2 years of age and older with moderately to severely active polyarticular juvenile idiopathic arthritis orencia may be used as monotherapy or concomitantly with methotrexate mtx orencia is indicated for the treatment of adult patients with active psoriatic arthritis psa orencia should not be administered concomitantly with tnf antagonists orencia is not recommended for use concomitantly with other biologic rheumatoid arthritis ra therapy such as anakinra" ;
    bl:association_type bl:ChemicalToDiseaseOrPhenotypicFeatureAssociation ;
    bl:provided_by <https://w3id.org/um/NeuroDKG> ;
    bl:relation schema:TreatmentIndication .
  <https://identifiers.org/drugbank:DB01281> bl:category bl:Drug .
}
sub:provenance {
   sub:assertion prov:wasAttributedTo orcid:0000-0002-1468-3557 .
}
sub:pubinfo {
   sub:sig npx:hasAlgorithm "RSA" ;
    npx:hasPublicKey "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCODwZkXojpEKwk7Ldj2oPPfCstvqrcpgCaTLo235K7ht9C7E1GCkLvUuL2b4VWXJTcZx/hxgDauR8hUeYq/lS6tfTL9yFZsnfl+PWYDyz7vv6N+wJVx2LL8bO6ntCjcOzvW2t2WUeF12Sb6b3I6uOYP0N8iQKts1WasY/yEYKAHQIDAQAB" ;
    npx:hasSignature "FbZUsRIWQk13ON0qa92JaJ7E2ZQGYsOxQ4F/Q9v+oRTGm3qiJXFfsiXRhs/7XNrwxWrdLMgPposqi1BtX8CE7IqhWTHR69HbkBdmZzZgYWC4xQ9lCM2GDCIqkXFqgHJhQnwnnzMezkBUokK4zH3RGT+LfQkRjy80LRqs+5K9it0=" ;
    npx:hasSignatureTarget this: .
  this: dc1:created "2021-06-12T12:38:34.922+02:00"^^xsd:dateTime ;
    dc1:creator orcid:0000-0002-1468-3557 ;
    nt:wasCreatedFromProvenanceTemplate <http://purl.org/np/RANwQa4ICWS5SOjw7gp99nBpXBasapwtZF1fIM3H2gYTM> ;
    nt:wasCreatedFromPubinfoTemplate <http://purl.org/np/RAA2MfqdBCzmz9yVWjKLXNbyfBNcwsMmOqcNUxkk1maIM> ;
    nt:wasCreatedFromTemplate <http://purl.org/np/RAManV5GZI01JKzW_IPcfOXoiFTcZMmsV7qTCLkdzr4Gs> .
}