https://w3id.org/np/RApC9zZU64P3Hf2IDjAhelbHS01p81pfFTRM87IcRWWbM/Head https://w3id.org/np/RApC9zZU64P3Hf2IDjAhelbHS01p81pfFTRM87IcRWWbM http://www.nanopub.org/nschema#hasAssertion https://w3id.org/np/RApC9zZU64P3Hf2IDjAhelbHS01p81pfFTRM87IcRWWbM/assertion https://w3id.org/np/RApC9zZU64P3Hf2IDjAhelbHS01p81pfFTRM87IcRWWbM http://www.nanopub.org/nschema#hasProvenance https://w3id.org/np/RApC9zZU64P3Hf2IDjAhelbHS01p81pfFTRM87IcRWWbM/provenance https://w3id.org/np/RApC9zZU64P3Hf2IDjAhelbHS01p81pfFTRM87IcRWWbM http://www.nanopub.org/nschema#hasPublicationInfo https://w3id.org/np/RApC9zZU64P3Hf2IDjAhelbHS01p81pfFTRM87IcRWWbM/pubinfo https://w3id.org/np/RApC9zZU64P3Hf2IDjAhelbHS01p81pfFTRM87IcRWWbM http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication https://w3id.org/np/RApC9zZU64P3Hf2IDjAhelbHS01p81pfFTRM87IcRWWbM/assertion http://id.crossref.org/issn/2041-1723 http://purl.org/dc/terms/title Nature Communications (Nat Commun) https://doi.org/10.1038/s41467-022-29206-7 http://purl.org/dc/terms/abstract A central question concerning natural competence is why orthologs of competence genes are conserved in non-competent bacterial species, suggesting they have a role other than in transformation. Here we show that competence induction in the human pathogen Staphylococcus aureus occurs in response to ROS and host defenses that compromise bacterial respiration during infection. Bacteria cope with reduced respiration by obtaining energy through fermentation instead. Since fermentation is energetically less efficient than respiration, the energy supply must be assured by increasing the glycolytic flux. The induction of natural competence increases the rate of glycolysis in bacteria that are unable to respire via upregulation of DNA- and glucose-uptake systems. A competent-defective mutant showed no such increase in glycolysis, which negatively affects its survival in both mouse and Galleria infection models. Natural competence foster genetic variability and provides S. aureus with additional nutritional and metabolic possibilities, allowing it to proliferate during infection. https://doi.org/10.1038/s41467-022-29206-7 http://purl.org/dc/terms/date 2022-03-21 https://doi.org/10.1038/s41467-022-29206-7 http://purl.org/dc/terms/isPartOf http://id.crossref.org/issn/2041-1723 https://doi.org/10.1038/s41467-022-29206-7 http://purl.org/dc/terms/title The induction of natural competence adapts staphylococcal metabolism to infection https://doi.org/10.1038/s41467-022-29206-7 http://purl.org/ontology/bibo/issue 13 https://doi.org/10.1038/s41467-022-29206-7 http://purl.org/ontology/bibo/volume 2022 https://doi.org/10.1038/s41467-022-29206-7 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://purl.org/spar/fabio/ResearchPaper https://orcid.org/0000-0002-1481-2996 http://schema.org/affiliation https://ror.org/0259fwx54 https://orcid.org/0000-0002-1481-2996 http://xmlns.com/foaf/0.1/name Konrad U. Förstner https://orcid.org/0000-0002-6937-6394 http://xmlns.com/foaf/0.1/name Julia García-Fernández https://orcid.org/0000-0002-7355-0674 http://xmlns.com/foaf/0.1/name Ana Eulalio https://orcid.org/0000-0002-8627-3813 http://xmlns.com/foaf/0.1/name Daniel Lopez https://orcid.org/0000-0003-2705-4781 http://xmlns.com/foaf/0.1/name Ivan C. Acosta https://ror.org/0259fwx54 http://xmlns.com/foaf/0.1/name ZB MED – Information Centre for Life Sciences: Cologne, DE https://w3id.org/np/RApC9zZU64P3Hf2IDjAhelbHS01p81pfFTRM87IcRWWbM/author-list http://www.w3.org/1999/02/22-rdf-syntax-ns#_1 https://orcid.org/0000-0002-1481-2996 https://w3id.org/np/RApC9zZU64P3Hf2IDjAhelbHS01p81pfFTRM87IcRWWbM/author-list__1 http://www.w3.org/1999/02/22-rdf-syntax-ns#_2 https://orcid.org/0000-0002-7355-0674 https://w3id.org/np/RApC9zZU64P3Hf2IDjAhelbHS01p81pfFTRM87IcRWWbM/author-list__2 http://www.w3.org/1999/02/22-rdf-syntax-ns#_3 https://orcid.org/0000-0002-8627-3813 https://w3id.org/np/RApC9zZU64P3Hf2IDjAhelbHS01p81pfFTRM87IcRWWbM/author-list__3 http://www.w3.org/1999/02/22-rdf-syntax-ns#_4 https://orcid.org/0000-0002-6937-6394 https://w3id.org/np/RApC9zZU64P3Hf2IDjAhelbHS01p81pfFTRM87IcRWWbM/author-list__4 http://www.w3.org/1999/02/22-rdf-syntax-ns#_5 https://orcid.org/0000-0003-2705-4781 https://w3id.org/np/RApC9zZU64P3Hf2IDjAhelbHS01p81pfFTRM87IcRWWbM/provenance https://w3id.org/np/RApC9zZU64P3Hf2IDjAhelbHS01p81pfFTRM87IcRWWbM/assertion http://www.w3.org/ns/prov#wasAttributedTo https://orcid.org/0009-0001-6755-0125 https://w3id.org/np/RApC9zZU64P3Hf2IDjAhelbHS01p81pfFTRM87IcRWWbM/pubinfo https://orcid.org/0009-0001-6755-0125 http://xmlns.com/foaf/0.1/name Johanna Sophie Mück https://w3id.org/np/RApC9zZU64P3Hf2IDjAhelbHS01p81pfFTRM87IcRWWbM http://purl.org/dc/terms/created 2025-06-25T12:53:52.514Z https://w3id.org/np/RApC9zZU64P3Hf2IDjAhelbHS01p81pfFTRM87IcRWWbM http://purl.org/dc/terms/creator https://orcid.org/0009-0001-6755-0125 https://w3id.org/np/RApC9zZU64P3Hf2IDjAhelbHS01p81pfFTRM87IcRWWbM http://purl.org/dc/terms/license https://creativecommons.org/licenses/by/4.0/ https://w3id.org/np/RApC9zZU64P3Hf2IDjAhelbHS01p81pfFTRM87IcRWWbM http://purl.org/nanopub/x/hasNanopubType http://purl.org/spar/fabio/ScholarlyWork https://w3id.org/np/RApC9zZU64P3Hf2IDjAhelbHS01p81pfFTRM87IcRWWbM http://purl.org/nanopub/x/introduces https://doi.org/10.1038/s41467-022-29206-7 https://w3id.org/np/RApC9zZU64P3Hf2IDjAhelbHS01p81pfFTRM87IcRWWbM http://purl.org/nanopub/x/wasCreatedAt https://nanodash.knowledgepixels.com/ https://w3id.org/np/RApC9zZU64P3Hf2IDjAhelbHS01p81pfFTRM87IcRWWbM http://www.w3.org/2000/01/rdf-schema#label Article: The induction of natural competence adapts staphylococcal metabolism to infection https://w3id.org/np/RApC9zZU64P3Hf2IDjAhelbHS01p81pfFTRM87IcRWWbM https://w3id.org/np/o/ntemplate/wasCreatedFromProvenanceTemplate https://w3id.org/np/RA7lSq6MuK_TIC6JMSHvLtee3lpLoZDOqLJCLXevnrPoU https://w3id.org/np/RApC9zZU64P3Hf2IDjAhelbHS01p81pfFTRM87IcRWWbM https://w3id.org/np/o/ntemplate/wasCreatedFromPubinfoTemplate https://w3id.org/np/RA0J4vUn_dekg-U1kK3AOEt02p9mT2WO03uGxLDec1jLw https://w3id.org/np/RApC9zZU64P3Hf2IDjAhelbHS01p81pfFTRM87IcRWWbM https://w3id.org/np/o/ntemplate/wasCreatedFromPubinfoTemplate https://w3id.org/np/RAukAcWHRDlkqxk7H2XNSegc1WnHI569INvNr-xdptDGI https://w3id.org/np/RApC9zZU64P3Hf2IDjAhelbHS01p81pfFTRM87IcRWWbM https://w3id.org/np/o/ntemplate/wasCreatedFromTemplate https://w3id.org/np/RAdU0hUGGpPxWxtO3n_c4loIpyd67K5_Tr7w5ul8sA-iY https://w3id.org/np/RApC9zZU64P3Hf2IDjAhelbHS01p81pfFTRM87IcRWWbM/sig http://purl.org/nanopub/x/hasAlgorithm RSA https://w3id.org/np/RApC9zZU64P3Hf2IDjAhelbHS01p81pfFTRM87IcRWWbM/sig http://purl.org/nanopub/x/hasPublicKey MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCUMHjfjDd5czAkLWmWQWazYxgcsBi7Etqzycae3evKX8LzOSYtY9pJWBW2GbkwyDwnr3BahzuYZQyF8YKl6Uj/7AebxwUMLjV6bMH9tgh/xenI0F7XzgTd6m8h01sBmV+ESFzssyiLp5bwsrWOivU+zkH+vM/oS1Vl2gaR2gbieQIDAQAB https://w3id.org/np/RApC9zZU64P3Hf2IDjAhelbHS01p81pfFTRM87IcRWWbM/sig http://purl.org/nanopub/x/hasSignature gmNpra9pCyS0nQZxXGXM9JBFvUFBCjgC5ptZT74P/g47UW1oXOfGLJnQfshacGYXVb2tyIjWY0x3xK9RMbG5MOXz4dO/NnrkUBvbB57ofwlpmQGHyg2k8RX8/E5lDuPhqFFdx/6xrCe9IYvz800kRC6wdwvTL4dOHJaxey58yjw= https://w3id.org/np/RApC9zZU64P3Hf2IDjAhelbHS01p81pfFTRM87IcRWWbM/sig http://purl.org/nanopub/x/hasSignatureTarget https://w3id.org/np/RApC9zZU64P3Hf2IDjAhelbHS01p81pfFTRM87IcRWWbM https://w3id.org/np/RApC9zZU64P3Hf2IDjAhelbHS01p81pfFTRM87IcRWWbM/sig http://purl.org/nanopub/x/signedBy https://orcid.org/0009-0001-6755-0125