. . . . . . . . . . . . . . . "p(MGI:Myod1) -> tscript(p(PFM:\"Mef2 Family\"))" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "1.4" . "Strikingly, activation of the MEF2 reporter by a fusion protein consisting of MyoD with the herpesvirus VP16 transactivation domain (MyoD-VP16) remained predominantly pRb-dependent (Figure 1b, columns 4 and 5), even though MyoD-VP16 alone activated the E-box reporter considerably more than did wild-type MyoD and pRb together (Figure 1a, columns 3 and 4). Moreover, MyoD-VP16 did not activate the MEF2 reporter to significantly greater levels in either the absence or the presence of pRb than did wild-type MyoD (Figure 1b, compare columns 2 and 3 with columns 4 and 5). Together, these findings indicate that pRb is specifically required for MyoD-mediated activation of MEF2 and that this process is not a direct function of the transactivation abilities of MyoD. MEF2 expression, DNA binding, and nuclear localization are not modulated by pRb" . . "Selventa" . . . . "2014-07-03T14:29:47.097+02:00"^^ . . .