sub:assertion {
  <http://purl.obolibrary.org/obo/DOID_3481> bl:category bl:Disease .
  sub:association rdf:object <http://purl.obolibrary.org/obo/DOID_3481> ;
    rdf:predicate bl:treats ;
    rdf:subject <https://identifiers.org/drugbank:DB00218> ;
    a rdf:Statement ;
    rdfs:label "moxifloxacin hydrochloride is a fluoroquinolone antibacterial indicated for treating infections in adults 18 years of age and older caused by designated susceptible bacteria in the conditions listed below community acquired pneumonia 1 1 skin and skin structure infections uncomplicated 1 2 1 3 complicated intra abdominal infections 1 4 plague 1 5 acute bacterial sinusitis 1 6 acute bacterial exacerbation of chronic bronchitis 1 7 to reduce the development of drug resistant bacteria and maintain the effectiveness of moxifloxacin hydrochloride and other antibacterial drugs moxifloxacin hydrochloride should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria 1 8 moxifloxacin hydrochloride is indicated in adult patients for the treatment of community acquired pneumonia caused by susceptible isolates of streptococcus pneumoniae streptococcus pneumoniae haemophilus influenzae moraxella catarrhalis staphylococcus aureus klebsiella pneumoniae mycoplasma pneumoniae chlamydophila pneumoniae see clinical studies 14 3 mdrsp isolates are isolates resistant to two or more of the following antibacterial drugs penicillin minimum inhibitory concentrations mic 2 mcg ml 2nd generation cephalosporins for example cefuroxime macrolides tetracyclines and trimethoprim sulfamethoxazole moxifloxacin hydrochloride is indicated in adult patients for the treatment of uncomplicated skin and skin structure infections caused by susceptible isolates of methicillin susceptible staphylococcus aureus streptococcus pyogenes see clinical studies 14 4 moxifloxacin hydrochloride is indicated in adult patients for the treatment of complicated skin and skin structure infections caused by susceptible isolates of methicillin susceptible staphylococcus aureus escherichia coli klebsiella pneumoniae enterobacter cloacae see clinical studies 14 5 moxifloxacin hydrochloride is indicated in adult patients for the treatment of complicated intra abdominal infections ciai including polymicrobial infections such as abscess caused by susceptible isolates of escherichia coli bacteroides fragilis streptococcus anginosus streptococcus constellatus enterococcus faecalis proteus mirabilis clostridium perfringens bacteroides thetaiotaomicron peptostreptococcus see clinical studies 14 6 moxifloxacin hydrochloride is indicated in adult patients for the treatment of plague including pneumonic and septicemic plague due to susceptible isolates of yersinia pestis see clinical studies 14 7 moxifloxacin hydrochloride is indicated in adult patients 18 years of age and older for the treatment of acute bacterial sinusitis abs caused by susceptible isolates of or moxifloxacin hydrochloride is indicated in adult patients 18 years of age and older for the treatment of acute bacterial sinusitis abs caused by susceptible isolates of streptococcus pneumoniae haemophilus influenzae moraxella catarrhalis see clinical studies 14 1 because fluoroquinolones including moxifloxacin hydrochloride have been associated with serious adverse reactions see warnings and precautions 5 moxifloxacin hydrochloride is indicated in adult patients for the treatment of acute bacterial exacerbation of chronic bronchitis abecb caused by susceptible isolates of methicillin susceptible or moxifloxacin hydrochloride is indicated in adult patients for the treatment of acute bacterial exacerbation of chronic bronchitis abecb caused by susceptible isolates of streptococcus pneumoniae haemophilus influenzae haemophilus parainfluenzae klebsiella pneumoniae staphylococcus aureus moraxella catarrhalis see clinical studies 14 2 because fluoroquinolones including moxifloxacin hydrochloride have been associated with serious adverse reactions see warnings and precautions 5 1 5 13 and for some patients abecb is self limiting reserve moxifloxacin hydrochloride for treatment of abecb in patients who have no alternative treatment options to reduce the development of drug resistant bacteria and maintain the effectiveness of moxifloxacin hydrochloride and other antibacterial drugs moxifloxacin hydrochloride should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria when culture and susceptibility information are available they should be considered in selecting or modifying antibacterial therapy in the absence of such data local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy" ;
    bl:association_type bl:ChemicalToDiseaseOrPhenotypicFeatureAssociation ;
    bl:provided_by <https://w3id.org/um/NeuroDKG> ;
    bl:relation schema:TreatmentIndication .
  <https://identifiers.org/drugbank:DB00218> bl:category bl:Drug .
}