@prefix dcterms: <
http://purl.org/dc/terms/
> .
@prefix this: <
http://purl.org/np/RAxBBJ2WkonyQNlXfdCAOaCi64J_xqgVGeaLjVQow9M88
> .
@prefix sub: <
http://purl.org/np/RAxBBJ2WkonyQNlXfdCAOaCi64J_xqgVGeaLjVQow9M88#
> .
@prefix np: <
http://www.nanopub.org/nschema#
> .
@prefix nt: <
https://w3id.org/np/o/ntemplate/
> .
@prefix npx: <
http://purl.org/nanopub/x/
> .
@prefix xsd: <
http://www.w3.org/2001/XMLSchema#
> .
@prefix rdfs: <
http://www.w3.org/2000/01/rdf-schema#
> .
@prefix orcid: <
https://orcid.org/
> .
@prefix prov: <
http://www.w3.org/ns/prov#
> .
sub:Head
{
this:
np:hasAssertion
sub:assertion
;
np:hasProvenance
sub:provenance
;
np:hasPublicationInfo
sub:pubinfo
;
a
np:Nanopublication
.
}
sub:assertion
{
sub:spi
a
<
https://w3id.org/linkflows/superpattern/terms/SuperPatternInstance
> ;
rdfs:label
"A regulatory element within the first intron of FTO affects IRX3 and IRX5 expression during early adipogenesis" ;
<
https://w3id.org/linkflows/superpattern/terms/hasContextClass
> <
http://purl.org/np/RAtsHwzNs36rGrLnoSbGrPD351Qw033Acoe4zmdXhsYlM#early-human-adipogenesis
> ;
<
https://w3id.org/linkflows/superpattern/terms/hasObjectClass
> <
http://purl.org/np/RAwkXiTv7qCtqOYzlR6ozZRGLRtG6mlogrYdRQ1E4dRDg#expression-of-genes-IRX3-and-IRX5
> ;
<
https://w3id.org/linkflows/superpattern/terms/hasQualifier
> <
https://w3id.org/linkflows/superpattern/terms/generallyQualifier
> ;
<
https://w3id.org/linkflows/superpattern/terms/hasRelation
> <
https://w3id.org/linkflows/superpattern/terms/affects
> ;
<
https://w3id.org/linkflows/superpattern/terms/hasSubjectClass
> <
http://purl.org/np/RAxLYvJ1JrRf2JAowYGbGJleQPmqtpXnXsIvse7GmLeT8#regulatory-element-within-the-first-intron-of-FTO
> .
}
sub:provenance
{
sub:activity
a
<
https://w3id.org/linkflows/superpattern/terms/FormalizationActivity
> ;
prov:used
sub:quote
, <
https://doi.org/10.1056/NEJMoa1502214
> ;
prov:wasAssociatedWith
orcid:0000-0003-2432-4125
.
sub:assertion
prov:wasGeneratedBy
sub:activity
.
sub:quote
prov:value
"The rs1421085 T-to-C single-nucleotide variant disrupts a conserved motif for the ARID5B repressor, which leads to derepression of a potent preadipocyte enhancer and a doubling of IRX3 and IRX5 expression during early adipocyte differentiation." ;
prov:wasQuotedFrom
<
https://doi.org/10.1056/NEJMoa1502214
> .
}
sub:pubinfo
{
sub:sig
npx:hasAlgorithm
"RSA" ;
npx:hasPublicKey
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npx:hasSignature
"MUs9dML4QrzQVnfT2hqnfkif+lpusIVT0o4c74M69kgNQmA0CXVRzUZIHcvavS/pMlobVFBhfkTQ7kHs5a0CZGVrvtOhQJYD17eXzg6dwD/LqdYNYErvWxduyvwInXMasXpDZdYkFtddAFt/5Vny6BSBoiIzclnGfGwahZhFmpg=" ;
npx:hasSignatureTarget
this:
.
this:
dcterms:created
"2021-10-27T10:22:03.671-07:00"^^
xsd:dateTime
;
dcterms:creator
orcid:0000-0003-2432-4125
;
npx:introduces
sub:spi
;
<
https://w3id.org/linkflows/reviews/isUpdateOf
> <
http://purl.org/np/RAxxJWyH8OdTJLs-ZY1q5jVq1OWFNOoLFvwEcUFyR8EEo
> ;
nt:wasCreatedFromProvenanceTemplate
<
http://purl.org/np/RAB_oy10D3XUP-zYlqGz7Uj58AsUXhEKeGqmRFg5LSgDM
> ;
nt:wasCreatedFromPubinfoTemplate
<
http://purl.org/np/RAA2MfqdBCzmz9yVWjKLXNbyfBNcwsMmOqcNUxkk1maIM
> , <
http://purl.org/np/RAOGu9Lh0BD4tbIRB9RG6RGRA_ObDh75NTbIqaWgxxs8M
> ;
nt:wasCreatedFromTemplate
<
http://purl.org/np/RAv68imZrEjfcp2rnEg1hzoBqEVc0cQMtp9_1Za0BxNM4
> .
}