dgn-np:NP60906.RAyp68BcgraLwqC7wc46BP-EvgyUfRjT79C8__Qpxh4Yc130_provenance {
  dgn-np:NP60906.RAyp68BcgraLwqC7wc46BP-EvgyUfRjT79C8__Qpxh4Yc130_assertion dcterms:description "[A preferential use of VL germline genes was noted for both ALkappa and lambda patients. There was a significant correlation between the use of the VlambdaVI germline donor, 6a and renal involvement as well as the Vlambda III gene, 3r with 'soft-tissue' AL. The use of a biased VL gene repertoire also correlated with clinical outcome, revealing important trends for predicting prognosis. The use of Vlambda II germline genes was associated with cardiac amyloidosis and affected survival adversely. The presence of multiple myeloma also correlated with a poor prognosis. The presence of renal disease, on the other hand, was associated with improved survival. Therefore, identification of the clonal VL gene in AL has important implications in determining clinical outcome.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en ;
    wi:evidence dgn-void:source_evidence_literature ;
    sio:SIO_000772 miriam-pubmed:12515719 ;
    prov:wasDerivedFrom dgn-void:gad-20130706 ;
    prov:wasGeneratedBy eco:ECO_0000203 .
  dgn-void:gad-20130706 pav:importedOn "2013-07-06"^^xsd:date .
  dgn-void:source_evidence_literature a eco:ECO_0000212 ;
    rdfs:comment "Gene-disease associations inferred from text-mining the literature."@en ;
    rdfs:label "DisGeNET evidence - LITERATURE"@en .
}